A Prospective Analysis of Toxicities and Quality of Life after Treatment in Advanced Carcinoma Cervix Patients Following Concurrent Chemoradiation with Weekly Cisplatin
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 6
Abstract
Introduction: Cervical cancer is the most frequently diagnosed cancer among women in India. Understanding quality of life (QOL) in women undergoing Chemoradiotherapy for cervical cancer will help in introducing interventions for better care and outcomes in these women. Aim: To study toxicities and quality of life after treatment in advanced carcinoma cervix patients following concurrent chemoradiation with weekly cisplatin Patients and Methods: Newly diagnosed patients with histologically confirmed carcinoma cervix, Patients with FIGO STAGE IIB TO IVA and no evidence of distant metastasis. Gynecological Oncologic group performance status of 0-3, Age less than 70 years, WBC count greater than 4000 cells/ml, An absolute neutrophil count greater than 37.5%, Platelet count of 100000 platelets/ml, Serum creatinine < 1.5mg/dl, Creatinine clearance more than 80 ml/min, Hemoglobin value >8 gm%. The patient treated with concurrent chemoradiation with weekly cisplatin Results: Out of the 45 patients only 6 patients developed grade 3 neutropenia (13.3%), 12 patients (26.7%) developed grade 2 neutropenia, and there were no incidences of grade 4 neutropenia, during radiation, 4(8.9%) patients developed grade 3 skin reaction and 3(6.7%) patients developed grade 1 skin reaction. The quality of life decreased during treatment. Conclusion: The patients who underwent chemoradiation experienced the reduction in quality of life during the treatment, but it was transient. The symptoms subsided and after the treatment patients have a better quality of life compared to pretreatment status. the toxicities of the treatment can be managed conservatively., which is comparable with global standards
Authors and Affiliations
Jayaraman Balan, T S Sudhiraj, Deepak George, Jewell Joseph, R Mahadevan
Keywords
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