A Prospective Single Blind Randomized Study on Prevention of Postoperative Nausea and Vomiting with Palanosetron versus Ondansetron in Patients undergoing Laparoscopic Surgery
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 3
Abstract
Context: In the modern era of surgical field laparoscopic surgeries are more frequently performed than open surgeries. Postoperative nausea and vomiting is a common complaint encountered in the patients who have undergone laparoscopic surgeries because of pneumoperitoneum created by CO2. A number of anti-emetics are given as prophylactic agents to prevent postoperative nausea and vomiting. Among them 5-hydroxytrypatmine type 3 receptor antagonists are highly effective in prevention and treatment of PONV. With this background we conducted a study for evaluating the effectiveness of two 5-HT3 receptor antagonists in prevention of PONV in patients undergoing laparoscopic surgeries under general anesthesia. Aim: To compare the efficacy and safety profile of two 5 HT3 antagonists namely palonosetron and ondansetron in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgeries. Settings & Design: This was a prospective, randomized, single-blind comparative study. Sixty patients of age group between 18-60 years of Ameri can Society of Anaesthesiologists physical status class I and II undergoing laparoscopic surgeries were enrolled. They were randomly allocated into two groups namely Group A and B with 30 patients in each group. Group A received 0.075mg of injection palonosetron and Group B received 4mg of injection ondansetron intravenously 30 minutes before induction of anaesthesia. Statistical Analysis used: Statistical work up was performed using the SPSS version 16. Student’s t –test was used for quantitative data and Chi- square test was used for qualitative data. P value of less than 0.05 was found to be statistically significant. Results: The incidence of PONV in group A (palonosetron) was found to be 13% which is lesser than group B (ondansetron) where the incidence was 23%. The need for rescue antiemetic was also comparatively lesser in group A than group B. (23% vs 51%). The number of complete responders were 26 (86%) and 23 (76%) for palonosetron and ondansetron respectively. Conclusion: Palonosetron is effective antiemetic for preventing PONV during the late postoperative period while compared to ondansetron.
Authors and Affiliations
Swarnalingam Thangavelu
Keywords
Related Articles
- EP ID EP471626
- DOI 10.21088/ijaa.2349.8471.4317.26
- Views 74
- Downloads 0
A Comparison of Dexmedetomidine with Midazolam for Sedation in Elderly Patients Undergoing Regional Anaesthesia
Chemically induced tranquillity improves acceptance of Regional Anaesthetic techniques. Intravenous sedative medications are useful for the same as positioning for surgery can be uncomfortable and spontaneous movements b...
Dexmeditomedine vs Esmolol for Hypotensive Anaesthesia in Oro-Maxillo Facial Surgeries in Tertiary Care Hospital, Kanchipuram District
Introduction: Oro-maxillofacial surgeries are done worldwide. Extensive blood loss is a major concern in these surgeries. To make these procedures uncomplicated we need a good co-operating surgical and anesthesiologist t...
Comparison between Trapezius Squeezing Test and Jaw Thrust as Indicators for Proseal Laryngeal Mask Airway in Paediatric Patients: A Single Blind Prospective Study
Aim: Present study was carried out to compare the efficacy of trapezius squeeze test and jaw thrust as clinical tests to indicate an adequate depth of anaesthesia for insertion of the Proseal laryngeal mask airway after...
Effect of Dexmedetomidine as an Adjuvant to Levobupivacaine in Spinal Anaesthesia for Infraumbilical Surgeries
Spinal anaesthesia is the preferred mode of anaesthesia for infraumbilical surgeries. Levobupivacaine is an isomer of racemic bupivacaine. Various adjuvants have been added to the local anaesthetics to prolong its effect...
Similitude and Disparity between Airtraq and McCoy Laryngoscope in Simulated Cervical Spine Injury during Tracheal Intubation: A Prospective Randomized Study
Background: The study aimed at comparing the efficacy of Airtraq with McCoy laryngoscope on ease of intubation with cervical immobilization in patients undergoing elective surgery. Methods: Sixty consenting American Soc...