A Prospective Study of Adverse Drug Reactions During First Six Months of Therapy due to HAART in HIV Infected Patients at a Tertiary Care Hospital in Indore, India
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Acquired Immunodeficiency Syndrome (AIDS) is a global problem; global statistics till March 2015 revealed that 36.9 million people were living with HIV; where 15 million people accessing antiretroviral therapy. From an antiretroviral perspective, HAART is a potent form of therapy but it often fails owing to non adherence. One way of increasing the adherence is by focusing on prevention of adverse effects wherever possible. Material and method: This is prospective, observational study conducted at a single ART centre of tertiary care hospital. The adverse drug reactions occurring during first six months following initiation of antiretroviral regimens were observed. Results: A total of 292 patients were recruited, out of which 132 had shown adverse drug reactions (ADR) to antiretroviral regimen. Out of these, gastrointestinal ADRs were the most common (41%) perceived reactions. A total 64 patients on Zidovudine developed anemia (10%), of which 26 patients required change in regimen. Sixteen patients received Nevirapine developed skin rash (5%) and two patient (0.6%) developed Steven Johnsons syndrome. Conclusion: Most of the antiretroviral associated ADRs were mild, suggesting a good tolerance to antiretroviral medicines. So, a proper counseling and proper observation during this initial phase could probably increase the adherence of patients with antiretroviral medication.
Authors and Affiliations
Sanjay Dubey, Shiv Shankar Sharma, Rahul Nagar, V P Pandey
Keywords
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