A Prospective Study of Effect of Cisplatin and Etoposide based Chemotherapy Regimen in End Stage Lung Cancer Patients in A Rural Tertiary Care Hospital
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Lung cancer is the most common cause of cancer-related deaths in women and men.Small-cell lung cancer constitutes 20% of lung cancers. Non-Small-cell lung carcinoma constitute 80% of all lung cancers. For advanced un-resectable and metastatic lung cancer which are unsuitable for curative treatment options, the standard first-line treatment is palliative chemotherapy. So the study was done to see the clinical improvement with Cisplatin and Etoposide regimen based chemotherapy in end stage lung cancer patients Material and Methods: 30 patients of end stage lung cancer were taken up for the study. There KPS scores were calculated and presenting chief complaints mainly in the form of cough, chest pain, dyspnoea and haemoptysis were assessed. The response assessment of patients was done on the above factors after giving 3 cycles of Cisplatin and Etoposide based chemotherapy. Results: Symptomatically 11 patients (37%) showed Complete response (CR) in at least one symptom.8 patients (26%) showed Partial Response (PR) in at least one symptom. 8 patients (26%) showed no improvement or worsening in any symptom (SD) and 3 patients (10%) showed worsening in at least one symptom (PD).Change in KPS score post chemotherapy was found to be statistically insignificant ( p=0.344) Conclusion: In a rural centre with resource poor patients, this regimen offers a reasonably good cost effective option for management of Lung Cancer mainly as a palliative therapy by improving the quality of life of such patients.
Authors and Affiliations
Abinav Dagar, Prachi singhal, Sameer Singhal, Dinesh Mehta, Sachin Bansal, Mohammad Zaeem Khan
Keywords
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