A Prospective Study of Association of Cancer Stem Cell Marker CD133 with Clinicopathological Profile in Lung Carcinoma Patients
Journal Title: Journal of Medical Research and Practice - Year 2017, Vol 6, Issue 4
Abstract
Objectives In India, lung carcinoma is the fifth most common tumour and the second most common tumour in males as per the Indian Council of Medical Research (ICMR) registry of 2002. It has been seen that CD133 expression in non-small cell lung cancer (NSCLC) and the presence of marker were linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in patients with NSCLC with platinum treatment. Hence, our objective was to detect association of cancer stem cell marker CD133 with staging in patients with lung carcinoma. Methods It was a pilot study where biopsies from 55 fresh previously untreated lung cancer patients visiting the Pulmonary Medicine Department of Era’s Lucknow Medical College and Hospital Lucknow & King George’s Medical University were taken for a period of 6 months, November 2015 to April 2016, after taking proper informed consent from them. Paraffin blocks were taken and stained by Haematoxylin and Eosin [Sigma] to make the histopathological diagnosis, and immunohistochemistry was done for the detection of CSC marker CD133[Daco]. Results Expression of stem cell marker CD133 with the staging of the tumour was observed in 62.5% of Stage I, 90% of Stage II, 94.1% of Stage III and 100% of Stage IV cases. Statistically, there was a significant association between CD133 expression and stage of disease (P < 0.001). It was found that diagnostic efficacy of CD133 expression in detection of any positive clinical stage to be 88.6% sensitive and 90.9% specific. Conclusion Strong CD133 expression correlates with higher stage of lung carcinoma making it a prognostic marker needing in-depth study.
Authors and Affiliations
Neema Tiwari, Nishi Tandon, A. N Srivastava
Keywords
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