A REVIEW ON ENHANCEMENT OF SOLUBILITY AND DISOLUTION RATE OF BCS CLASS-II DRUG BY SOLID DISPERSION AND NONAQEOUS GRANULATION TECHNIQUE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Solid dispersion, defined as the dispersion of one or more active ingredient in a carrier or matrix at solid state, is an efficient strategy for improving dissolution of poorly water-soluble drugs for enhancement of their bioavailability. Non aqueous granulations technique means size enlarged granules containing MCC with CCS showed higher solubility and dissolution rate compared to other conventional formulations such as tablets or capsules, solid dispersion which can be prepared by various methods has many advantages. Fairly soluble drugs in gastrointestinal (GI) media exhibit complete oral absorption, and thus good bioavailability. About 40% of drugs are not soluble in water in practice and therefore are slowly absorbed, which results in insufficient and uneven bioavailability and GI toxicity. For BCS class II drug, solubility is a crucial rate limiting factor to achieve its desired level in systemic circulation for pharmacological response. Thus, problematic solubility of BCS class II drug is a main challenge for dosage. This review give detail information to improve the BCS class II drug solubility by solid dispersion method and non aqueous granulation methods are ease and efficiency is most promising and routinely employed technique to resolve the solubility problems of BCS class II drug.
Authors and Affiliations
Chakravarthi V, Duraivel S
Keywords
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