A Review on Role of Advanced Glycation End products (AGEs) in Rheumatoid Arthritis
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2015, Vol 3, Issue 1
Abstract
Rheumatoid arthritis (RAa) is a systemic inflammatory connective tissue disease with polyarthritis as a prominent feature; however, extra-articular symptoms and signs are always present. Aadvanced glycation end products with ability of cross-linking of proteins characteristic fluorescence and reaction with AaGEe-specific receptor RAaGEe (receptor for AaGEes). AaGEes action as well as AaGEe formation is directly related to both to inflammation and oxidative stress. RAaGEe is a 35-kDa polypeptide whose gene is located at the junction of the class II and III HLAla regions on chromosome. ligation of RAaGEe has been shown to activate p21ras and mitogen-activated protein (MAaP) kinase, and stimulate nuclear translocation of the transcription factor NF-κB, thereby, resulting in the transcription of target genes thus may induce chronic cellular activation and tissue damage.
Authors and Affiliations
Ravinder Kumar , Sandeep Arora , Pratima Syal , Mayank Sippy
Keywords
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- EP ID EP596699
- DOI 10.15415/jptrm.2015.31001
- Views 115
- Downloads 0
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