A REVIEW: SYNTHESIS AND MEDICINAL IMPORTANCE OF 1,4-BENZOTHIAZINE ANALOGUES
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
The ultimate beneficiary of scientific advances is discovering new and better therapeutic agents. 1,4-benzothiazine forms an important class ofheterocyclic system, contains both N and S. Consequently, there have been various efforts for the production of novel 1,4-benzothiazine derivativespossessing various biological activities such as anti-hypertensive, anti-HIV, anti-inflammatory, antimicrobial, anti-rheumatic, ATP-sensitive potassiumchannel opener, cardiovascular, cytotoxic, immunomodulator, neuroprotective, antioxidant, antimalarial and aldose reductase inhibitor etc. As a partof an ongoing effort toward finding novel pharmacological active agents, it was thought worthwhile to synthesize hybrids of 1,4-benzothiazine.Keywords: 1,4-Benzothiazine, Ring expansion reaction, Biological activity, 2-aminothiophenol.Â
Authors and Affiliations
Monika Maheshwari, Anju Goyal
Keywords
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