DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF KAEMPFERIA GALANGA L EXTRACT AS AN ANTI-INFLAMMATION (PROSTAGLANDIN E2 AND TUMOR NECROSIS FACTOR ALPHA) ON OSTEOARTHRITIS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 5
Abstract
Objective: The purpose of this study was to compare the effectiveness of the rhizome extract against inflammatory markers such as tumor necrosis factor (TNF)-alpha and prostaglandin E2 (PGE2) with meloxicam in patients with osteoarthritis at knee. Materials and Methods: This study designed two phases as follows: The preparation of rhizome extract in a capsule dosage form which was then followed by double-blind clinical trials, randomized controlled, pre- and post-test design (18 cases) using the WOMAC scores for pain, to markers of inflammation using an enzyme-linked immunosorbent assay method. Results: The results did not reveal any significant differences in pain scores, stiffnesses, and physical function impairment between the intervention (the rhizome extract) and control groups (meloxicam), it either did not reveal any significant differences in the parameters of inflammatory marker TNF alpha and PGE2 among the groups. Conclusion: The rhizome extract had the same effect on pain, stiffness, physical interference as meloxicam, and on PGE2 as well as on the inflammatory marker TNF-alpha. Therefore, this extract can be used as an alternative herbal medicine for osteoarthritis.
Authors and Affiliations
NURPUDJI A TASLIM , M NATSIR DJIDE , YUSNITA RIFAI , AKMAL NOVRIAN SYAHRUDDIN , YOSEFA RIA RAMPO , MURNI MUSTAMIN , SIGIT ANGRIAWAN
Keywords
Related Articles
- EP ID EP604718
- DOI -
- Views 181
- Downloads 0
A COMPARATIVE SCREENING AND EVALUATION OF THE TOTAL PHENOLICS, FLAVONOIDS, AND ANTIOXIDANT PROPERTIES IN THE SEED EXTRACTS OF PUNICA GRANATUM L., PSIDIUM GUAJAVA L., AND VITIS VINIFERA L.
Objectives: The synthetic antioxidants produce numerous adverse effects to overcome these adverse effects and the use of natural products is the alternative. In this study, the evaluation of total phenolics, flavonoid co...
SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES
Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investig...
OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM
Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucoc...
DEVELOPMENT AND CHARACTERIZATION OF NEVIRAPINE LOADED AMORPHOUS SOLID DISPERSIONS FOR SOLUBILITY ENHANCEMENT
Objective: The present study entails the development of nevirapine (NVP)-loaded solid dispersions for improvement of solubility and in vitro profile. Methods: Solid dispersions were prepared through blending with a hydr...
IN VITRO EVALUATION OF ANTIOXIDANT-MEDIATED APOPTOSIS ON CANCER CELLS AND NON-TOXICITY OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA RETZ AND PYROGALLOL
Objective: Antioxidants are very important for human health, and hence, external supplementation is recommended to protect cells from the deleterious effects of excessive reactive oxygen species conditions that are capab...