A simple validated UV spectrophotometric method for quantitative analysis of Levetiracetam in pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 5
Abstract
In the present study simple, precise, accurate, economical and reliable UV spectrophotometric method has been developed for the estimation of Levetiracetam in tablet dosage form. The drug shows maximum absorption (maximum λmax) at 209.0 nm in triple distilled water and obeys Beer’s law in the concentration in the range of 2-10 μg /mL with good correlation coefficient (r2=0.9982). The results of analysis were validated by recovery studies. The recovery was found to be 99.53-100.41. The relative standard deviation was found to be < 2.0 % in all cases. The proposed spectrophotometric method was validated statically as per the ICH Q2 (R1) guidelines with respect to linearity, specificity, accuracy, precision and robustness. The proposed method validation were found to be accurate, highly specific and can be used for the reliable quantification of Levetiracetam in bulk form and routine analysis of pharmaceutical formulations.
Authors and Affiliations
Panchumarthy Ravisankar, A. Niharika, H. Anusha, V. Himaja, S. K. Afzal Basha
Keywords
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