A simple validated UV spectrophotometric method for quantitative analysis of Levetiracetam in pharmaceutical dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 5
Abstract
In the present study simple, precise, accurate, economical and reliable UV spectrophotometric method has been developed for the estimation of Levetiracetam in tablet dosage form. The drug shows maximum absorption (maximum λmax) at 209.0 nm in triple distilled water and obeys Beer’s law in the concentration in the range of 2-10 μg /mL with good correlation coefficient (r2=0.9982). The results of analysis were validated by recovery studies. The recovery was found to be 99.53-100.41. The relative standard deviation was found to be < 2.0 % in all cases. The proposed spectrophotometric method was validated statically as per the ICH Q2 (R1) guidelines with respect to linearity, specificity, accuracy, precision and robustness. The proposed method validation were found to be accurate, highly specific and can be used for the reliable quantification of Levetiracetam in bulk form and routine analysis of pharmaceutical formulations.
Authors and Affiliations
Panchumarthy Ravisankar, A. Niharika, H. Anusha, V. Himaja, S. K. Afzal Basha
Keywords
Related Articles
- EP ID EP33337
- DOI -
- Views 327
- Downloads 0
Investigation of physiochemical and vegetative properties of two barley lines
Physiochemical and vegetative properties of two barely lines in “EBYT88-17 AND EBTY88-20” purchased from agriculture center of Golestan Province, Iran were investigated for enzyme activity, sprouting energy and suitabil...
Assessment of Hepatoprotective Potential of Solanum xanthocarpum (whole plant) Linn. Against Isoniazid & Rifampicin Induced Hepatic Toxicity in Wistar rats
Introduction and objective: The scientific assessment of medicinal plants used in the preparation of folk remedies has contributed modern medicine with effective pharmaceuticals for the treatment of diseases. Objective...
Renal Calculi: A Comprehensive Review
Renal calculi is nothing but a crystalline structures of calcium oxalate (C2H2CaO5) associated with risk factors like dehydration, high fat diet, high salt, animal protein and obesity. Due to the formation crystalline...
Bleaching of Echium amoenum Fisch & C.A.Mey by Gel anoinic, macroprus absorbing and macroprus anion resin for production of a drink by using date syrup
Date syrup is a suitable and natural sweetener for using in food stuffs formulation and improvement of its nutritional and sensory characteristics. In this research, to produce Echium amoenum Fisch & C.A.Mey drink with...
Antimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6- methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones
7-Chloro-2-(substituted)-3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl) quinazolin-4(3H)-ones 1- 12 have been prepared from the substituted acids 1(a-l), which were converted to substituted acetyl chlorides 2(a-l) and cyc...