A STEP CLOSER TO LOOKUP ALTERNATE OR ADJUVANT THERAPY FOR EPILEPSY: INTRANASAL DELIVERY OF SOLID-LIPID NANOPARTICLES OF PITAVASTATIN TO APPRAISE ANTIEPILEPTIC PROPERTIES IN MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 12
Abstract
Statins are most effective lipid lowering drug, but it also exert pleiotropic effect exhibiting neuroprotective action on epilepsy and further pauperism for alternate or adjuvant therapy for epilepsy is requisite since complication associated with existing antiepileptic drug (AEDs) is of global concern and black box warning have been issued by food and drug administration (FDA) regarding use of antiepileptic drug, hence we are evaluating antiepileptic properties of solid-lipid nanoparticle (SLNs) of pitavastatin (PTS) via intranasal route, as dose related myopathy exerted by statins are major limitations. Electroshock seizure (ICES) and maximal electroshock seizure (MES) test have been performed to assess the antiepileptic properties of the test formulation whereas force swim test (FST) and rota rod test is comported to assess antidepressant properties and motor activity. In ICES test, seizure threshold current (STC) is increased when compared to control group where as in MES test duration of hind limb extension (HLE) significantly reduced as compared to control. FST and rota rod test did not show any positive effect on depression and motor activity, hence SLNs of PTS could be potential alternate or add-on therapy for epilepsy and statins are devoid of side effects exerted by long term medication of AEDs.
Authors and Affiliations
Ashif Iqubal , Mohammad Iqubal , Ratendra Kumar , Shamim Ahmad
Keywords
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- EP ID EP159107
- DOI 10.7897/2230-8407.0612159
- Views 98
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