A Study of Anti-inflammatory effect of Heparin and Enoxaparin on Experimentally Induced acute Inflammation in Albino Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Objective: To evaluate and compare anti-inflammatory effect of Heparin and Enoxaparin with the standard drug Diclofenac sodium. Methodology: Rat paw edema induced by carrageenan was the experimental model. Albino rats weighting 130 to 180 grams of either sex were taken and divided into 4 groups of 6 rats each. Heparin 800 units/kbw was given to test group1, Enoxaparin 200 mcg/kbw was given to test Group II, Diclofenac sodium 25mg/kbw was given to standard group and 0.5ml normal saline was given to control group. Rats were injected intraperitonially (ip) with respective drugs 30minutes prior to administration of carrageenon. 0.1ml of 1%carrageenan was injected into the sub-plantar space of rat right hind paw. Rat paw volumes were measured at 0, 1, 2, 3 hours with the help of mercury plethysmometer. Results: Anti-inflammatory effect is expressed as percentage of inhibition of rat paw edema. Percentage of inhibition of rat paw edema at 3hours was 66% with Enoxaparin and 51% with Heparin and 78% for Diclofenac sodium. Conclusion: Enoxaparin and heparin have significant anti-inflammatory activity and enoxaparin shows more anti-inflammatory effect than heparin but less than Diclofenac sodium.
Authors and Affiliations
Dr. A. B. Suguna1, Dr. Sandya Kiran2
Keywords
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