A Study of Association of C-Peptide with Diabetic Peripheral Neuropathy
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background: The aim of our study was to evaluate the relationship between C-peptide and DPN in community-based patients with type 2 diabetes. Methods: In total, 220 consecutive type 2 diabetic patients treated by our regional medical consortium were enrolled. DPN was assessed by clinical symptoms, signs, and electromyography. Results: Fasting C-peptide, 2-h postprandial C-peptide and ΔC-peptide (i.e., 2-h postprandial C-peptide minus the fasting C-peptide) serum concentrations in the non-DPN group were significantly higher than those in the clinical DPN group (all P ≤ 0.040) and the confirmed DPN group (all P < 0.002). The three C-peptide parameters were independently associated with DPN (all P < 0.05) after adjusting for age, sex, diabetes duration, smoking status, systolic pressure, body mass index, angiotensin-converting enzyme inhibitors/ angiotensin receptor blocker use, fasting plasma glucose, HbA1c, triglyceride and estimated glomerular filtration rate. Compared with the ΔC-peptide quartile 1 (reference), patients in quartile 3 (odds ratio [OR], 0.110; 95% confidence interval [CI] 0.026–0.466; P = 0.003) and quartile 4 (OR, 0.012; 95% CI 0.026– 0.559; P = 0.007) had a lower risk of DPN after adjusting for the confounders. Conclusion: C-peptide was negatively associated with DPN in community-based type 2 diabetic patients.
Authors and Affiliations
Dr Prasad Potdukhe
Keywords
Related Articles
- EP ID EP284347
- DOI -
- Views 72
- Downloads 0
A Cross Sectional Study of the Prevalence of Allergic Conjunctivitis in Allergic Rhinitis
Allergic rhinitis (AR) is common condition affecting 20-30% of the population. This condition affects not only the nose but also the sinuses, ear and eyes in many ways. Though Allergic conjunctivitis (AC) is highly preva...
Routine Ilionguinal and Iliohypogastric Nerve Excision in Lichenstein Hernia Repair - A Prospective Study of 50 Cases
Chronic inguinal neuralgia is one of the most significant complications following inguinal hernia repair. Subsequent patient disability can be severe & may often require numerous interventions for treatment. The purpose...
Clinicopathological Profile of Endometrial Carcinoma: A Regional Cancer Centre Experience
The incidence of endometrial carcinoma is rising worldwide and more so in developing countries. One hundred and twenty four (124 cases) were analyzed in A.H. Regional Cancer Centre, Cuttack to find out different histopat...
Platelet-Rich Fibrin: Role in Periodontal and Pulpal Regeneration
Platelets are reservoirs of growth factors and cytokines and play a crucial role in wound healing and regeneration of tissues. Literature review suggests an important role of platelet concentrates in periodontal and pulp...
A Comparative study between Retroperitoneoscopic pyelolithotomy and Percutaneous nephrolithotomy in the management of solitary large renal pelvic calcul
Background: Percutaneous nephrolithotomy (PCNL) is considered gold standard for single large renal pelvic calculi. In this laparoscopic era Retroperitoneoscopic pyelolithotomy (RP) can be considered in selected such pati...