A study of effect of insulin therapy on the endothelial dysfunction in the type II diabetic patients at tertiary health care centre
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 2
Abstract
Background: Diabetes is an independent risk factor for cardiovascular disease1. Hyperglycemia2 and insulin resistance Aims and Objectives: To Study effect of insulin therapy on the endothelial dysfunction in the type II diabetic patients at tertiary health care centre. Methodology: This was a cross-sectional study carried out in the department Medicine of a tertiary health care centre in the type II diabetic patients during the one year period i.e. June 2017 to June 2018 , all the diabetic patients either on oral hypoglycemic drugs or oral hypoglycemic drugs were randomly selected, oral hypoglycemic drugs (OH) were 35 and oral hypoglycemic drugs and insulin(OH+I) 15, The statistical analysis done by unpaired t-test and analyzed by SPSS 19 version. Result: In our study we have seen that the majority of the patients were in the age group of 50-60 were 27.78% followed by 40-50 were 25.93%, >60 were 20.37%, 30-40 were 16.67%, 20-30 were 9.26%. The majority of the patients were Male i.e. 59.26% and Female were 40.74% . The patients in the Oral Hypoglycemic (OH) were 35 (64.81) and OH+ Insulin (OH + I) were 19 (35.19). The levels of MDA (Mean ±SD) were significantly lower i.e. 1.93 ± 0.92 and 3.12 ± 1.34 (t=3.36,df=48,p<0.0001), FRAP (Mean ±SD) -0.82 ± 0.38 and 0.45 ± 0.15 (t=4.56,df=48,p<0.001), NO (Mean ±SD) - 18.23 ± 3.42 and 13.34 ± 4.21 (t=5.24,df=48,p<0.001) respectively in the OH and OH + I groups. Conclusion: It can be concluded from our study that the patients on the insulin treatment were significantly less NO level and more in the oxidative stress, enzymes like FRAP and MDA level are low. Hence it indicated that insulin treatment group is having more endothelial dysfunction and more oxidative stress.
Authors and Affiliations
Vijay Mohan M, Mohammad Rafi
Keywords
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- EP ID EP442161
- DOI 10.26611/1002829
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