A Study of Effect of Organism Specific Sepsis on Platelet count and Platelet indices in Neonates
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Background: Changes in platelet parameters induced by culture proven and probable neonatal sepsis have been used for an early diagnosis to prevent complications and to administer timely treatment. The role of platelet indices in sepsis has been documented in literature in adult studies however in neonates it has not been extensively studied in culture proven sepsis. We conducted this study to find out the prevalence of thrombocytopenia, MPV, PDW in culture proven neonatal sepsis. Material and Methods: A total of 25 newborns (sepsis group) and 25 healthy newborns (control group) were evaluated in this study. The groups were analysed with regards to significant differences in the values of mean platelet volume (MPV). A p value of < 0.05 was considered statistically significant for all results. Results: The study revealed statistically significant MPV in neonates with sepsis as compared to healthy neonates. Conclusion: Neonatal sepsis often leads to thrombocytopenia and changes in platelet indices. It acts as one of the earliest non- specific indicator of neonatal sepsis. High MPV and PDW have a high specificity in identification of sepsis. Due to scarcity of literature with reference to organism specific response in neonatal sepsis we conducted this study to find out the prevalence of thrombocytopenia, MPV and PDW in culture proven sepsis in neonates.
Authors and Affiliations
Priyanka Anand
Keywords
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