A Study of Effect of Ormeloxifene in Dysfunctional Uterine Bleeding and Dysmenorrhoea in Women of Reproductive Age Group
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Introduction: Dysfunctional uterine bleeding (DUB) is a state of abnormal uterine bleeding without any clinically detectable organic, systemic and iatrogenic cause (Pelvic pathology,e.g. tumor, inflammation or pregnancy is excluded). Ormeloxifene has been evaluated for the management of menorrhagia but was seldom compared with progesterone. This study was an attempt to find out the cost-effectiveness of ormeloxifene against medroxyprogesterone acetate (MPA). Aims & Objectives :To evaluate the efficacy and side effects of Ormeloxifene in cases of dysfunctional uterine bleeding and dysmenorrhoea in women of reproductive age group and compare it with Medroxyprogesterone Acetate. Materials &Methods:100 women of reproductive age group attending the gynaecology out patients department satisfying inclusion criteria were enrolled for this study, which was done over a period of one year (June 2016 to May 2017) in the Department of Obstetrics and Gynaecology, Bardhaman Medical College & Hospital. 50 women randomly selected were given Ormeloxifene& the rest 50 women were given Medroxyprogesterone Acetate. Results: Significant reduction of post-treatment menstrual blood loss , dysmenorroea, endometrial thickness & drug related side-effects among Ormeloxifene group compared to Medroxyprogesterone group. Ormeloxifene is more cost-effective than Medroxyprogesterone acetate. Conclusion: Ormeloxifene is suitable for the treatment of dysfunctional uterine bleeding and dysmenorrhoea in women of reproductive age group with effective therapeutic efficacy, convenient dosage schedule, lesser sideeffects and more cost-effectiveness compared to Medroxyprogesterone Acetate.
Authors and Affiliations
Biswarup Tah, Bibek Mohan Rakshit, Debobroto Roy
Keywords
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- EP ID EP465010
- DOI 10.9790/0853-1802024953.
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