A study of efficacy of nasal continuous positive airway pressure in bronchiolitis
Journal Title: MedPulse -International Medical Journal - Year 2019, Vol 6, Issue 2
Abstract
Objective: To evaluate the efficacy of nasal continuous positiveairway pressure (n CPAP) in decreasing respiratory distress inbronchiolitis. Design: Randomized controlled trial. Participants: 72 infants (age <1y) hospitalized with a clinical diagnosis of bronchiolitis were randomized to receive standard care, or n CPAP in addition to standard care, in the first hour after admission. 23 parents refused to give consent for participation. 2 infants did not tolerate n CPAP. Intervention: The outcome was assessed after 60 minutes. IfnCPAP was not tolerated or the distress increased, the infant was switched to standard care. Analysis was done on intention-to-treat basis. Main outcome measures: Change in respiratory rate, Silverman-Anderson score and a Modified Pediatric Society of New Zealand Severity Score. Results: 14 out of 32 in n CPAP group and 5 out of 35 in standard care group had change in respiratory rate ≥10 (P=0.008). The mean (SD) change in respiratory rate [8.0 (5.8) vs5.1 (4.0), P=0.02] in Silverman-Anderson score [0.78 (0.87) vs0.39 (0.73), P=0.029] and in Modified Pediatric Society of New Zealand Severity Score [2.5 (3.01) vs. 1.08 (1.3), P=0.012] were significantly different in the n CPAP and standard care groups, respectively. Conclusion: n CPAP helped reduce respiratory distress significantly compared to standard care.
Authors and Affiliations
Mani Shankar, Ashok Kumar
Keywords
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