A study of haemodynamic response on low dose dexmedetomidine infusion in laparoscopic surgery
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 2, Issue 2
Abstract
Background: Dexmedetomidine is a potent and highly selective α-2 adrenoceptor agonist with sympatholytic, sedative, amnestic and analgesic properties which has been described as a useful and safe adjunct in many clinical applications. It is the most recently developed and commercialized agent in this pharmacological class. Aims and Objectives: To study the haemodynamic response on low dose dexmedetomidine infusion in laryngoscopic surgery. Materials and Method: In the present study we selected total 60 patients aged 20-60 years of either sex admitted for laparoscopic surgery under general anesthesia with ASA physical grade I or II. All the selected patients were randomly allocated in three groups containing 20 patients each. Control group in which patients received normal saline 0.9% infusion during the procedure. In Group A the patients received dexmeditomidine infusion 0.2 mcg/kg/hr and in Group B the patients received dexmeditomidine infusion 0.4 mcg/kg/hr. The base line parameters of the patients including heart rate (HR), pulse oximetry (SPO2), Noninvasive Systolic blood pressure (SBP), Diastolic Blood pressure (DBP), Mean Arterial pressure (MAP) and End tidal Co2 (Etco2) were measured and recorded on a prestructured proforma. The parameters were also measured intra operatively and post operatively. During the intra operative period the hemodynamic parameters were measured after every 15min whereas in post operative period measurement was done at every 4 hourly. Results: The mean baseline systolic blood pressure in control group was 123.22±11.88 mm of Hg, in group A was 123.55±10.02 mm of Hg and in group B was 123.09±11.74 mm of Hg. It was observed that there was rise in post operative systolic blood pressure in control group. However systolic blood pressure in group A and B was stable. The difference observed in post operative systolic blood pressure in control group and group A and B was statistically significant. The fall in post operative diastolic blood pressure was statistically significantly in group A and B as compared to control group. The mean arterial pressure was falling with time and the difference observed between control group and Group A and B was statistically significant. The baseline heart rate in control and A and B group was statistically not significant. There was rise in the heart rate after intubation whereas the heart rate was decreasing in group A and B and the difference observed was statistically significant. Conclusion: The Low dose infusion of dexmedetomidine has better control on hemodynamic parameters as compared to normal saline infusion.
Authors and Affiliations
Prakash Kisanrao Surwade, Abhinay Ramchandra Harankhedkar
Keywords
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