Effect of preanesthetic medication Clonidine vs gabapentin on hemodynamic responses following laryngoscopy and tracheal intubation:A comparative study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 8, Issue 3
Abstract
Objective: Comparing the effect of Clonidine and Gabapentin as premedication in attenuating hemodynamic responses following laryngoscopy and tracheal intubation was primary objective. Methods: In this randomized, prospective study, patients aged 18-60years with American Society of Anaesthesiologists grade I or II were included and randomized into three groups (Control, Clonidine (0.2mg) and Gabapentin (900mg).Control group received standard of care; those randomized to other groups received either Clonidine or Gabapentin as premedication, 120mins prior to the procedure. Heart rate (HR), systolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP) were monitored. Results: Thirty patients in each group with Mean±SD age of 40.5±14.9years, and body weight 53.5±5.3Kgs were included. HR in control group reached maximum (111.33beats/min) at 1min after laryngoscopy and remained above baseline till 10min after laryngoscopy and intubation. Maximum and minimum HR was 92.83 and 84.10beats/min with Gabapentin and 85.53 and 76.33beats/min with Clonidine were noted at 1 min after laryngoscopy, respectively. Highest mean SBP 151.33±8.47mmHg, DBP 100.33±6.70mmHg and MAP 117.11±5.04mmHg was in control group at 1 min after laryngoscopy. Lowest mean SBP of 109.36±5.89mmHg, DBP 72.06±5.40mmHg and MAP 84.50± 3.92mmHg was seen with Gabapentin at 10 min after laryngoscopy. HR, SBP, DBP and MAP differed significantly (p<0.0001) among the study groups and to time (p<0.0001). Conclusion: Gabapentin and Clonidine at given doses, as premedication, 120min before surgery are effective in blunting hemodynamic response to laryngoscopy and endotracheal intubation. Clonidine has greater impact on HR; Gabapentin has significant attenuating effect on the SBP, DBP and MAP
Authors and Affiliations
Chauhan A, Konduri S, Bollampally B
Keywords
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- EP ID EP450170
- DOI 10.26611/1015835
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