Attenuation of haemodynamic response to intubation with oral clonidine and oral atenolol
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 1
Abstract
Objective: The aim of this study is to attenuate the heamodynamic response to laryngoscopy and endotracheal intubation using oral atenolol and oral clonidine, to study the extent of change in haemodynamic response and to observe if there are any untoward effects of such premedication. Design: A comparative study of oral atenolol and oral clonidine done to compare the attenuation of cardiovascular response during laryngoscopy and intubation. Duration: November 2016 to December 2017. Setting: Department of Anesthesia, Bhaskar Medical College, Ranga Reddy, Telangana. Participants: 50 adult patients undergoing various elective surgeries of ASA Grade – I, Mallampatti Grade– I were selected and informed consent was taken for all the cases. Patients were of both sexes and age ranging from 18-60 years. Methods: This study was done in 2 Groups. Group I consisted of 25 patients where atenolol 0.75 mg per kg body weight was given orally 3 hours before scheduled time of surgery. Group II consisted of 25 patients where clonidine 3-3.5 micrograms per kg body weight was given orally 90 minutes before scheduled time of surgery. The drugs given in premedication were injection glycopyrrolate 0.01 mg per kg body weight, midazolam 0.04 mg per kg body weight and ondansetron 0.08 mg per kg body weight. Induction of anaesthesia was achieved by intravenous thiopentone sodium given in a dose of 5 mg per kg body weight. Tracheal intubation was facilitated with intravenous suxamethonium 1.5 to 2 mg per kg bodyweight. Haemodynamic parameters (blood pressure, Heart rate, mean arterial pressure) were recorded at the specific intervals. Results: Patients who received oral atenolol did not show a significant increase in the various haemodynamic parameters. Patients who received oral clonidine showed a higher increase in haemodynamic parameters compared to patients who received oral atenolol. The haemodynamic parameters returned to the basal value at the end of 5 minutes in the atenolol group where as in the clonidine group it took more than 5 minutes to return to the basal value and it has less effect on the heart rate when compared atenolol group. Conclusion: Oral atenolol in a dose of 0.75 mg per kg body weight given 3 hours before induction of anaesthesia is more effective in attenuating haemodynamic response to laryngoscopy and endotracheal intubation when compared to oral clonidine.
Authors and Affiliations
Sunil Bablu Pulla, Mohammed Abdul Moiz
Keywords
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- EP ID EP520889
- DOI 10.26611/10159113
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