Significance of lactate and its clearance within 6 hours of admission in children with sepsis and septic shock admitted to PICU
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 3, Issue 1
Abstract
Aims and Objective: To measure the serum lactate levels in patient with sepsis and septic shock. To determine and correlate lactate clearance within 6 hours of admission with sepsis and septic shock, with PICU mortality. Methods: Admission to PICU (aged >2months and <18yrs) were studied between 2015-2016 after obtaining written informed consent from parents. Serum lactate estimation was done at admission and 6 hours after admission, lactate clearance (lactate level at admission – lactate level after 6 hours of admission/ lactate level at admission * 100) in first 6 hours of hospitalization was correlated with PICU mortality. Results: 27 out of 55 patients admitted to PICU died due to sepsis and septic shock, 69% died among those with delayed/ poor clearance( clearance <30%) compared to 30% in those with good lactate clearance and 0.1% died despite good lactate clearance and 9.2% improved despite poor lactate clearance. Conclusion: Lactate levels and its clearance within 6hours of admission predicts significantly the mortality in PICU in patients admitted with sepsis and septic shock
Authors and Affiliations
Roopa B Mangshetty, Aishwarya Patil, Sharanagouda Patil
Keywords
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