A study of higher circulatory levels of uric acid in cardio vascular disease (CVD) patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Uric acid is an end product of purine catabolism. It is observed that increased uric acid formation is associated with various inflammatory conditions. Anthropometric parameters as well lipid profile did not show any correlation with CVD. While Blood glucose and related variables were significantly increased in CVD. Increased uric acid levels were observed in CVD group as compared to controls [6.88 (±2.17)/ 4.29 (±1.04)]. No difference in serum uric acid levels were observed in CVD patients according to gender. Post menopausal women showed high uric acid levels than premenopausal [4.89 (±1.10)/ 5.81 (±1.26]. The main enzyme associated with uric acid production is xanthine oxidase. Instead of just formation of uric acid, xanthine oxidase is also involved in various other mechanisms like oxidative stress, endothelial dysfunction etc, which are associated with development of CVD. Conclusion: Higher uric acid levels were observed in CVD patients compared to controls. Higher levels of uric acid were found in female CVD patients in post menopausal condition than premenopausal.
Authors and Affiliations
Deepali Amarsinh Vidhate, Aarati Chavan, Arpith Murarka, Honey Mittal, Becky Thomas, James Thomas
Keywords
Related Articles
- EP ID EP362229
- DOI -
- Views 136
- Downloads 0
Regulatory role of HDL on systemic inflammatory response in adult bacterial sepsis
Background: Inspite of the recent advances available in the intensive care units (ICU) there is still an increasing incidence of sepsis and sepsis related deaths. Recent studies suggest that high density lipoprotein (HDL...
A study on genotypic frequency of 12-lipoxygenase polymorphisms and 12-HETE levels in type II diabetes
Background: Diabetes mellitus describes a group of metabolic diseases characterized by a progressive insulin secretory defect due to insulin resistance resulting in high glucose levels in the blood. Approximately 90% of...
Enzymatic and non-enzymatic antioxidants changes in precancerous and cancerous lesions of oral cavity
Background: Involvement of ROS in the development of tobacco related oral carcinogens is speculated. Little is known about the status of ROS scavengers or antioxidant enzymes in association with precancerous and cancerou...
Comparison of serum leptin concentration and electrolytes in pre-eclampsia and normal pregnancy
Background: Preeclampsia is one of the leading causes of maternal as well as perinatal morbidity and mortality. Studies have shown that leptin has also been implicated in the pathogenesis of many of the maternal features...
Serum lipid profile in oral submucous fibrosis - A case control study
Background: Oral Sub Mucous Fibrosis (OSMF) is a chronic, debilitating disease characterised by juxtaepithelial fibrosis of the oral cavity. It is a precancerous condition a generalized pathological state of the oral muc...