A study of higher circulatory levels of uric acid in cardio vascular disease (CVD) patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Uric acid is an end product of purine catabolism. It is observed that increased uric acid formation is associated with various inflammatory conditions. Anthropometric parameters as well lipid profile did not show any correlation with CVD. While Blood glucose and related variables were significantly increased in CVD. Increased uric acid levels were observed in CVD group as compared to controls [6.88 (±2.17)/ 4.29 (±1.04)]. No difference in serum uric acid levels were observed in CVD patients according to gender. Post menopausal women showed high uric acid levels than premenopausal [4.89 (±1.10)/ 5.81 (±1.26]. The main enzyme associated with uric acid production is xanthine oxidase. Instead of just formation of uric acid, xanthine oxidase is also involved in various other mechanisms like oxidative stress, endothelial dysfunction etc, which are associated with development of CVD. Conclusion: Higher uric acid levels were observed in CVD patients compared to controls. Higher levels of uric acid were found in female CVD patients in post menopausal condition than premenopausal.
Authors and Affiliations
Deepali Amarsinh Vidhate, Aarati Chavan, Arpith Murarka, Honey Mittal, Becky Thomas, James Thomas
Keywords
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