Adenosine deaminase levels in serum and cerebrospinal fluid of patients with tuberculous meningitis
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 1
Abstract
Background: Tuberculosis is one of the oldest human diseases with the highest mortality rate among infectious diseases and is caused by bacteria Mycobacterium tuberculosis complex and usually affects the lungs, although other organs are involved in up to one-third of cases. Adenosine deaminase (ADA) is now being recognized as a marker of cell mediated immunity particularly as a marker of T lymphocyte activation. Adenosine deaminase levels (ADA) have also been considered by several researchers to differentiate tubercular disease from non-tubercular. Purpose: 1) To evaluate the usefulness of enzyme Adenosine deaminase in diagnosis of Tuberculous Meningitis. Methodology: A case control study was conducted and a total of 100 patients were included in the study in which 50 suspected and diagnosed cases of tubercular meningitis patients and 50 healthy subjects taken as controls. Estimation of ADA in both serum and CSF was done by GUISTI AND GALANTI METHOD Results: In the present study, the Mean±SD of serum ADA in TBM cases was 37.54±10.81 and in controls was 11.56±3.240. This implied that tuberculous 56 meningitis patients had high levels of serum ADA levels than controls and the P value was <0.0001. Simultaneous estimation of serum and CSF-ADA have an added advantage to diagnose TB meningitis and differentiate between TBM and pyogenic meiningitis. Conclusions: To conclude, ADA is an enzyme that increases in TB because of the stimulation of T- cell lymphocytes by microbial antigens, SERUM and CSF ADA can be used for early diagnostic marker of Tubercular Meningitis.
Authors and Affiliations
Zeenath Begum . , P V Satya Narayana
Keywords
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- EP ID EP521658
- DOI 10.26611/1002914
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