A study of mixed connective tissue disorders at the department of medicine of a tertiary health care centre
Journal Title: Medpulse International Journal of Medicine - Year 2017, Vol 3, Issue 3
Abstract
Background: The concept of mixed connective tissue disease (MCTD) as a separate immune-mediated connective tissue disease (CTD) was first introduced by Gordon C. Sharp and coworkers > 40 years ago, but there is still no consensus regarding the disease definitions, the classification criteria, or the relationship with other CTDs. Aims and Objectives: To study the profile of mixed connective tissue disorders observed in the department of Medicine of a tertiary health care centre Materials and Method: In the present study all the patients with suggestive mixed connective tissue disease were selected and were tested for serum antibody in high titer (mean =1:149,200) to ribonucleoprotein. Total 28 patients were selected for the study. The emographic details including age, sex was recorded on a prestructured proforma. Presenting Features of the patients with mixed connective tissue disease was also recorded. Laboratory Findings of various laboratory test performed were also recorded. The collected data was entered in the Microsoft excel and was analyzed and presented with appropriate graphs and tables. Results: Male: female ratio was 1: 3.67. Majority of the patients were in the age group of 21-50 years of age. Majority of the patients presented with Arthritis/arthralgia (53.57%) followed by Raynaud phenomenon (17.86%) and Cutaneous lupus erythematosus (10.71%). All patients Antinuclear antibody tests was positive. The Epidermal nuclear IgG deposition was positive in 85.71% patients. Erythrocyte sedimentation rate (>30 mm per hour) was increased in 71.43%. Esophageal dysmotility occurred in 60.71% of the patients. Abnormal pulmonary function tests were present in 57.14% percent of those tested. Conclusion: Thus we conclude that mixed connective tissue disease was common in young female presenting most commonly Arthritis/arthralgia, Raynaud phenomenon and Cutaneous lupus erythematosus. On laboratory test antinuclear antibody tests, epidermal nuclear IgG deposition and raised erythrocyte sedimentation rate were common findings.
Authors and Affiliations
Janrao Bhaurao Rajput, Vinod Ramchandra Baviskar
Keywords
Related Articles
- EP ID EP248912
- DOI -
- Views 69
- Downloads 0
In hospital Mortality and correlates among patients admitted for Acute Coronary Syndrome in South India
Context: Acute Coronary Syndromes (ACS) is one of the most common causes of a visit to the emergency department among adults. Majority of the Acute Coronary Syndromes are managed in Govt facilities. However, studies on t...
Study of incidence of anemia, hypocalcemia; Type II diabetes mellitus and ECG changes in healthy women staff at tertiary care hospital in western Maharashtra
Background: In this study, we have screened the healthy women staff in tertiary care hospital for deficiencies of haemoglobin, serum calcium levels, raised blood sugar levels and ECG changes which gets unnoticed in day t...
Prevalence of peripheral vascular disease in type 2 diabetes mellitus and correlation with risk factors
Objective: To study the prevalence of Peripheral Vascular Disease in patients with Type 2 Diabetes Mellitus without overt foot disease. To study the correlation of Peripheral Vascular Disease with various risk factors. T...
Assessment of osteoporosis knowledge in perimenopausal females attending outpatient department at tertiary care hospital at central Gujarat
Background: Osteoporosis is a major health issue affecting the perimenopausal women, however not addressed effectively by them due to inadequate knowledge about the condition. Aims and Objectives: Evaluation of knowledge...
A study on the prevalence of dilated cardiomyopathy in chronic alcoholics
Background: Dilated cardiomyopathy (DCM) is an important cause of congestive heart failure and accounts for up to 25% of all cases of CHF. The incidence of DCM appears to be increasing and is associated with significant...