A study of prevalence and pattern of anemia in primary hypothyroidism
Journal Title: International Journal of Medical Science and Public Health - Year 2018, Vol 7, Issue 2
Abstract
Background: Anemia is a common disorder affecting Indian population which may be further influenced by hypothyroidism. Hematopoietic system is one of the primary systems affected by hypothyroidism and anemia could be its first manifestation. Numerous mechanisms are involved in the pathogenesis of this anemia that can be microcytic, macrocytic, and normocytic. We designed this study to investigate the incidence of anemia its morphological pattern in hypothyroidism patients. Objectives:The objectives were to investigate the incidence of anemia and its morphological pattern in patients with overt and subclinical hypothyroidism. Materials and Methods: A prospective observational study was conducted in patients presenting with overt or subclinical primary hypothyroidism in King George Medical University from August 2016 to September 2017. Patients with age >18 years and newly diagnosed cases of subclinical hypothyroidism were included. Patients with secondary causes for anemia or patients under treatment with drugs that might affect blood parameters were excluded. Results: In our present study, female predominance was 82% with more common age group between 31 and 40 years. The incidence of anemia was found to be 69% in the overt hypothyroid group and 56% in the subclinical hypothyroid group. Normocytic normochromic (53%) was the most common type of anemia, followed by microcytic (30%) and macrocytic anemia (27%). Serum iron levels were significantly low in both overt and subclinical hypothyroid groups. Serum anti-thyroid peroxidase (TPO) positivity was 65.53%. Anemia was severe in cases with high thyroid-stimulating hormone (TSH). Conclusion: Normocytic normochromic anemia is the most common type of anemia in hypothyroid patients. The incidence of anemia was found to be 69% in the overt hypothyroid group and 56% in the subclinical hypothyroid group. Presence of anemia in subclinical hypothyroidism was almost as high as in patients with overt hypothyroidism. TPO antibodies were linked with higher likelihood of developing anemia in hypothyroidism. Higher TSH values were associated with more severe anemia.
Authors and Affiliations
Rohit Anand, Arvind Kumar Mishra, Abbas Ali Mahdi, Shailendra Prasad Verma, Kamlesh Kumar Gupta
Keywords
Related Articles
- EP ID EP448434
- DOI 10.5455/ijmsph.2018.1131728122017
- Views 74
- Downloads 0
Knowledge, attitude, and practice of blood donation among college students in Puducherry
Background: Blood donation refers to the process of collection, testing, preparing, storing blood, and blood components. The shortage of blood in India is due to an increase in the demand, with fewer voluntary blood dono...
Toxoplasmosis in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome patients in a tertiary care hospital of Pune city of Maharashtra, India
Background: Toxoplasmosis in immunocompetent people is generally asymptomatic, but in immunocompromised patients including those suffering from human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/ AIDS),...
Objective Structured Clinical Examination as an assessment method for undergraduate medical students
Background: One of the most important objectives for University of Dammam is to send competent graduated physicians into the society, which cannot be accomplished without assessments of the clinical skills of the stude...
A study of the prevalence of overweight, obesity, and their associations with socioeconomic status among young men residing in a rural area, Kancheepuram District, Tamil Nadu, India
Background: Non-communicable diseases such as diabetes and hypertension are increasing worldwide. Overweight and obesity may be assessed using internationally accepted criteria developed by the World Health Organization...
An interventional study on knowledge and attitude regarding organ donation among medical students
Background: Organ donation to date remains a sensitive issue among the general public and medical community. In both group’s lack of awareness persists despite the significance of organ shortage faced by the health care...