A Study of Spectrum of Histomorphological Changes in Endometrial Tissue – An Experiences In A Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Background: Endometrium That Lines The Uterine Cavity Is One Of The Most Dynamic Tissue In The Human Body,Is Characterised By Cyclic Responses To The Hormones That Leads To Cell Proliferation, Differentiation And Death, Response To The Sex Steroids,Thus An Interesting Tissue For Histopathology Study. The Microscopic Picture On Histopathological Examinationdifferswith Age Of The Patient, Type And Dose Of The Hormonal Therapy. The Aim Of The Study Is To Study The Histopathological Spectrum Of Endometrial Tissue Biopsies In D &C. Materials & Methods: This Is A Descriptive, Cross Sectional Study Over A Period Of 6 Months From July 2017 To December 2017. Total 100 Tissue Samples Of Dilatation & Curettage,Done For Diagnostic And Therapeutic Purpose, At The Department Of Gynaecology And Obstetrics. These Samples Were Received To Department Of Pathology Dr.Psims & Rf, Chinnaoutpalli, India. After Fixation In 10% Formalin For 12-24 Hours And The Entire Tissue Was Taken For Routine Tissue Processing And H&E Staining, Histopathological Diagnosis Was Made .This Studywas Approved By Institutional Ethical Committee. Results: Total Of 100 Biopsies Were Categorized Into Non-Neoplastic And Neoplastic Lesions. Non-Neoplastic Were 89(89%) Cases And Neoplastic Were 11(11%) Cases. Higherincidence Of Morphological Variations Inendometrial Biopsies Were Noted In The Peri And Post Menopausal Age Of Women’s Life. The Glandular And Stromaldyssynchrony Of The Endometrium Was The Commonest Change That Was Encountered In All The Age Groups. Variations In The Endometrial Pathology Microscopically, In All The Samples From Reproductive Age To Post-Menopausal Were Mostly Due To The Excessive External Use Of Steroid Hormones That Were Given By The Gynaecologist Prior To The D & C To Relive The Signs And Symptoms Based On Clinical Diagnosis Without Finding The Underlying Aetiology. Conclusion: External Hormonal Therapy Given By The Treating Gyencologist For Symptomatic Relief Of Clinical Signs And Symptoms, Influence The Endometrial Tissue And Sometimes It May Mask The Underlying Indigenous Pathology Of Endometrium And At Point May Miss The Hyperplastic And Neoplasticlesions In Early Age Which Leads To The Advancement Of Disease. Histopathological Examination Of Endometrial Biopsy Is Amajor Diagnostic Tool In Evaluation Of Changes Of Endometrium And A Specificdiagnosis Could Help The Physician To Plan Therapy Forsuccessful Management Of Before It Progress Into Further Carcinoma
Authors and Affiliations
Dr. T . Bharath1, Dr. U. Parameswari Babu, Dr. Sp Naga Praphulla3
Keywords
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