A study to determine the accuracy of cytological diagnosis of CNS lesions by squash smears and correlation with histopathology
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 4, Issue 1
Abstract
Background: The intraoperative squash smear technique or frozen section study of brain parenchymal lesions are methods for obtaining a rapid diagnosis of normal or abnormal tissue and can be made within few minutes of the biopsy reaching the laboratory. Based on the report the neurosurgeon may undertake further biopsies or modify the type and extent of surgery. The study was undertaken to determine the accuracy of cytological diagnosis of CNS lesions by squash smears when compared to final histopathological diagnosis in our institute. Aim of the study: To determine the accuracy of cytological diagnosis of CNS lesions by squash smears and compare with the final histopathology. Materials and Methods: This was a prospective study done in the department of Pathology at ASRAM Medical College, Eluru, over a period of two years. A total of 52 CNS lesions which were surgically excised by burr hole or by craniotomy were studied initially by squash smearsand simultaneous frozen sections followed by routine histopathological examination and the results were compared. Results: In the present study, CNS lesions were most common in 21-30 years with 18 cases (34.6%). Intracranial lesions were 48 (92.3%) and intraspinal lesions were 4 (7.6%). Astrocytomas were the most common tumors constituting 14 (26.9%) cases, followed by meningiomas 8 (15.3%) and pituitary adenomas 5(9.6%).A total of 49 (94.2%) cases were diagnosed correctly on squash preparations. Inadequate specimen/technical error was seen in 3 (5.7%) cases where squash preparations failed. Conclusion: Intraoperative squash preparation for diagnosing central nervous system lesions is a rapid and valuable technique with a high degree of accuracy.
Authors and Affiliations
PVB Rama Lakshmi, KVN Srikanth, Ramesh Teegala
Keywords
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