Acromegaly: the effect of somatostatin analogues on tumour volume shrinkage
Journal Title: OncoReview - Year 2016, Vol 6, Issue 4
Abstract
Acromegaly is a rare disease, caused by growth hormone (GH) hypersecretion and secondarily elevated insulin-like growth hormone 1 (IGF-1) level. Nearly all patients with acromegaly suffer from somatotroph pituitary adenoma. The main goal of treatment is to normalise both GH and IGF-1 levels, which reduces symptoms, complications and mortality. Transsphenoidal selective adenomectomy performed by an experienced neurosurgeon is the first-line therapy of choice. Therapy with somatostatin analogues (SSA) is used as a neoadjuvant treatment prior to surgery and in a persistent disease following the surgery.
Authors and Affiliations
Przemysław Witek, Marta Gutowska
Keywords
Related Articles
- EP ID EP186904
- DOI 10.5604/01.3001.0009.5058
- Views 215
- Downloads 0
Terapie celowane wysoko zróżnicowanych guzów neuroendokrynnych
Guzy neuroendokrynne (NETs, neuroendocrine tumors) stanowią heterogenną grupę nowotworów o różnej biologii i rokowaniu. Terapia zaawansowanych raków neuroendokrynnych jest ograniczona. Leczenie chirurgiczne, bezpośrednia...
Aromataze inhibitors in the treatment of breast cancer
The main goal for hormonal therapy of breast cancer is to inhibit action of endogenous estrogens to breast cancer cells. Discovery of hormonal receptors and knowledge of their biological role employment to manner hormona...
Side effects control in the chemotherapy with everolimus: single-center experience
BACKGROUND: Renal cell carcinoma (RCC, renal cell carcinoma) accounts for 80–85% of neoplasms arising from the kidney. Everolimus, one of the selective mTOR kinase inhibitors, was recently approved for the treatment of p...
Nadciśnienie tętnicze indukowane terapią sunitinibem
Nadciśnienie tętnicze jest częstą chorobą współistniejącą u chorych na raka nerki oraz częstym powikłaniem terapii sunitinibem. Blokowanie szlaku zależnego od VEGF prowadzi do dysfunkcji śródbłonka, zmniejszenia wytwarza...
Selected psychosocial aspects of life of patients with a stoma
Cancer causes huge problems, physical and mental nature mainly. In particular, we cannot forget about the functioning of these patients in the social and spiritual spheres. The increasing trend of incidence of rectal can...