Activity of the Antiseptic Polyhexanide Comparing Younger and Elderly Patients
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 12, Issue 4
Abstract
The antiseptic polyhexanide was investigated in a placebo-controlled, prospective, and randomized double-blind study on patients with bacteria-contaminated wound types 2 - 4 comparing younger (< 65 years old, n=28) and elderly (≥ 65 years old, n=8) patients. The wound dressing with a 0.2 % polyhexanide/macrogolum solution was investigated in comparison to Ringer´s solution on days 0, 2, 4, 8, 11, and 15. Standardized swabs were taken on days 0, 2, 8 and 15 and investigated for microorganisms. An additive wound score for the condition of the wound base and the wound margin was determined. The use of polyhexanide led to a faster improvement of the wound score and a better reduction in microorganisms on the wound surfaces. This could also be observed in the subgroups of patients with different age. The findings suggest, that polyhexanide is also effective for the use in elderly patients.The care of geriatric patients is nowadays increasingly important, including the fight against infectious diseases. In the elderly patient, infections are usually more severe than in young people and end more often lethal. This can be due to many causes. The immune system ages, affecting both cell-mediated and humoral immunity. In addition, malnutrition, impaired organ function, and eventual polymedication play a significant role. As part of surgical procedures, the geriatric patient is at particular risk of infection. Patients 65 years or older have a 2.5-fold increased risk of infection complications. Respiratory and urinary tract infections, but also postoperative wound infections, occur more frequently in this age group. Postoperative wound infection accounts for around 17 % of nosocomial infection and affects 2 - 5 % of patients after surgery [1].Antiseptics are effective against a broad spectrum of germs. They are characterized by a low development of resistance. The use of antiseptics has therefore come to the fore in the local treatment of infections.The antiseptic polyhexanide has been shown to be more bactericidal and tissue compatible than other antiseptics. In a first placebo-controlled, prospective, and randomized double-blind study on patients with bacteria-contaminated wound types 2-4, no deterioration of wound healing was observed in either group[2]. Polyhexanide also led to a significant reduction in micro-organisms on soft-tissue wound surfaces [3]. In order to assess the suitability of polyhexanide for elderly patients, a reevaluation of these findings was performed. The results of patients younger than 65 years were compared with those who were older.The study was performed in accordance with the declaration of Helsinki. Patients (n=36) were admitted to the study with a bacterially contaminated or infected soft tissue wound of type 2 (clean contaminated after radical debridement), type 3 (still contaminated) or type 4 (dirty i.e. purulent wound)[4]. The age of the patients ranged from 19 to 89 years. Results of patients younger than 65 years (n=28) and 65 years or older (n=8) were analyzed separately. After a clinical evaluation a measurement of the wound area in cm2 and a photographic documentation of the baseline status were performed. A standardized collection of a swab specimen was taken and the size of the wound was determined by planimetry. Wound dressing was applied using cotton dressing pads moistened with Ringer´s or polyhexanide solution. An aqueous stock solution of 20 % polihexanide and 1% macrogolum was prepared ready for use by adding 2 ml of the mixture to 1000 ml Ringer solution (0.2%), giving a dilution of 0.4 mg/ml for the active ingredient polihexanide.
Authors and Affiliations
Fabry W, Heppner HJ, Reimer C, Kock HJ, Vahlensieck W
Keywords
Related Articles
- EP ID EP593740
- DOI 10.26717/BJSTR.2019.12.002274
- Views 157
- Downloads 0
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