Acute and sub-acute toxicity studies of Actaea acuminata H. Hara roots
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been traditionally used in the treatment of various ailments especially in CNS related diseases. A survey of literature revealed that no scientific evidence exists on the safety of A. acuminata. The present investigations were undertaken with an objective to evaluate acute and sub-acute toxicity of methanol extract of A. acuminata roots in rats. After acute administration of 2000 mg/kg, p.o. of methanol extract to rats, behavioural changes were observed every hour for the first 6 h and every day for 14 days. In this acute toxicity studies, no behavioural changes were observed in animals. In sub-acute toxicity study, the methanol extract was administered to rats at the dose of 1000 mg/kg, p.o. for 28 days, and its effects on body weight, behavioural signs and histopathological parameters were evaluated. Sub-acute toxicity studies revealed no significant difference in the body weight of all the rats. Toxicity signs such as piloerection, salivation and lacrimation were not observed. Histopathology examination of different organs (liver, kidney, spleen, lungs, brain, heart and testes) from both normal and treated groups revealed some architectural changes and detrimental effects in all organs of methanol extract treated animals. The crude methanol extract is a complex mixture of chemical constituents, thus, detailed investigations are needed in future to evaluate whether toxic effects are attributed to bioactive constituents or inactive part of methanol extract of A. acuminata.
Authors and Affiliations
Dipak Biswas, Deepak Kumar and Suresh Kumar
Keywords
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