Advanced bone age as an indicator facilitates the diagnosis of precocious puberty
Journal Title: Jornal de Pediatria - Year 2018, Vol 94, Issue 1
Abstract
Objective Diagnosis of central precocious puberty has always been challenging in clinical practice. As an important method in the diagnosis of central precocious puberty, luteinizing hormone-releasing hormone stimulation test is complex and time-consuming. In many cases, clinical traits are inconsistent with luteinizing hormone-releasing hormone stimulation test results, therefore not reliable for diagnosis. In this study, the authors intended to find an indicator that predicts the results of the luteinizing hormone-releasing hormone stimulation test among subjects with early pubertal signs. Methods Cases of 382 girls with early breast development before 8 years old and luteinizing hormone-releasing hormone stimulation test before 9 years old were included and underwent follow-up tests. Patients with peak luteinizing hormone level ≥5IU/L were considered positive in the luteinizing hormone-releasing hormone stimulation test. Anthropometric data, body mass index, bone age evaluation, blood hormones levels of luteinizing hormone, estradiol, follicle-stimulating hormone, and uterine and ovarian volumes were analyzed. Results Subjects with positive results in the initial test demonstrated early bone maturation, accelerated growth, and elevated basal blood luteinizing hormone, estradiol, and follicle-stimulating hormone levels, when compared with subjects with negative results in the initial test. Subjects with positive results in the follow-up test presented a more advanced bone age and more accelerated linear growth, when compared with subjects with negative results in the follow-up test. Conclusions According to the statistical analysis, advanced bone age is the most effective predictor of the result of luteinizing hormone-releasing hormone stimulation test.
Authors and Affiliations
Gui-Mei Li
Keywords
Related Articles
- EP ID EP482203
- DOI 10.1016/j.jped.2017.03.010
- Views 109
- Downloads 0
Impulse oscillometry and obesity in children
Objective To compare impulse oscillometry system parameters of normal-weight children with overweight and obese children. Method All participants were submitted to the evaluation of lung function (spirometry and impulse...
Temporal and spatial evolution of maternal and neonatal mortality rates in Brazil, 1997–2012
Objective Maternal and neonatal mortality are important public health issues in low-income countries. This study evaluated spatial and temporal maternal and neonatal mortality trends in Brazil between 1997 and 2012. Met...
Adolescents’ physical activity is associated with previous and current physical activity practice by their parents
Objective The purpose of this study was to determine whether parents’ current and previous physical activity practice is associated with adolescents’ physical activity. Methods The sample was composed of 1231 adolescent...
Health self-perception and its association with physical activity and nutritional status in adolescents
Objective To evaluate the association between total physical activities, physical activity in free time and nutritional status with self-perceived health in adolescents of both genders. Methods This is a quantitative st...
Risk factors associated with growth failure in the follow-up of very low birth weight newborns
Objective To determine risk factors during neonatal hospital stay and follow-up associated with failure to thrive in the first year of life of very low birth weight newborns. Methods Study of preterm very low birth weig...