Advancing cancer research using bioprinting for tumor-on-a-chip platforms
Journal Title: International Journal of Bioprinting - Year 2016, Vol 2, Issue 2
Abstract
There is an urgent for a novel approach to cancer research with 1.7 million new cases of cancer occurring every year in the United States of America. Tumor models offer promise as a useful platform for cancer research without the need for animal models, but there remains a challenge to fabricate a relevant model which mimics the structure, function and drug response of human tumors. Bioprinting can address this need by fabricating three-dimensional constructs that mimic tumor heterogeneity, vasculature and spheroid structures. Furthermore, bioprinting can be used to fabricate tissue constructs within microfluidic platforms, forming “tumor-on-a-chip” devices which are ideal for high-throughput testing in a biomimetic microenvironment. Applications of tumors-on-a-chip include facilitating basic research to better understand tumor development, structure and function as well as drug screening to improve the efficiency of cancer drug discovery.
Authors and Affiliations
Stephanie Knowlton, Ashwini Joshi, Bekir Yenilmez, Ibrahim Tarik Ozbolat, Chee Kai Chua
Keywords
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