Adverse effect of Diclofenac sodium on weight and volume of kidneys of adult swiss albino mice
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2017, Vol 24, Issue 1
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common pain relief medicines in the world. Every day lots of people use them for relief from headaches, sprains, arthritis symptoms, and other daily discomforts. In addition to reducing pain, NSAIDs also lower fever and reduce swelling. NSAIDs block the effects of enzymes, specifically Cox-1 and Cox-2 enzymes which play a key role in making prostaglandins leading to less swelling and less pain. But there are risks and side effects with NSAIDs which includes side effects associated with GIT, CVS and Kidney. In this study, adverse effect of Diclofenac sodium, which is one of the most commonly used NSAID, on weight and volume of kidneys of adult Swiss albino mice is demonstrated. It is studied in both, therapeutic as well as more than therapeutic doses, keeping in mind its inappropriate use because of over the counter availability. It is a case control study In this, adult Swiss albino mice were divided into four groups; one group served as control ( Group D) while each of the remaining three groups were given Diclofenac sodium, 1 mg/ Kg( Group A); 2mg/ Kg (Group B) and 4mg/ kg (Group C) body weight of, for 15 days. All animals were kept in proper living conditions necessary for optimal growth. Weight of animals was recorded before giving medicine i.e. day 1 and again on day 15. Then animals were sacrificed and their kidneys were extracted. Weight and volumes of kidneys were recorded and change pattern in four sets was observed. This short term study showed one of the potential side effects of Diclofenac sodium in the form of increase in weight and volume of kidneys due oedematous changes and cellular toxicity.
Authors and Affiliations
A D Kannamwar, G L Maske, I V Ingole
Keywords
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