AETIOLOGICAL FACTORS AND CLINICOPATHOLOGICAL PROFILE OF GALLBLADDER MALIGNANCY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 36
Abstract
BACKGROUND Early stages of gall bladder cancer are difficult to detect due to the absence of appropriate symptoms and signs. Previous studies have reported the correlation of clinical parameters, dietary habits and socioeconomic status of subjects to incidences of gall bladder cancer. Elucidation of various regional aetiological parameters as well as clinical presentation and histopathology of gall bladder malignancy will help in precise diagnosis of this disease in concerned patients. MATERIALS AND METHODS This retrospective descriptive study was carried out with both prospective (n= 87) and retrospective (n= 110) data analysis over a period of one and three years respectively. RESULTS Manifestation of this disease was mostly observed in middle-aged groups of subjects. Multiparous female individuals were found to be more predisposed to this disease than others. Incidences of gall bladder carcinoma were also found to be affected by dietary habits and socioeconomic status with most of the patients hailing from rural habitats. Gall stones were present in 80% of cases diagnosed with gall bladder cancer. Most of these patients were diagnosed with metastasising or infiltrating adenocarcinoma. Only single incidences of papillary and adenosquamous carcinoma of the gall bladder was found in two patients. CONCLUSION Results obtained in this study indicate that aetiological factors causing gall bladder carcinoma are continuously changing for a population subgroup with corresponding alterations in lifestyle, exposure to toxins and dietary habits. In this study, conclusive diagnosis of gall bladder cancer was provided by laparoscopic examinations. However, further investigations are required to determine the preventable factors causing the widespread manifestations of this disease.
Authors and Affiliations
Abhishek Jina, Santosh Upreti
Keywords
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- EP ID EP545097
- DOI 10.14260/jemds/2018/902
- Views 99
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