Aggressive orbital Burkitt’s lymphoma with rapid onset proptosis
Journal Title: Medpulse International Journal of Ophthalmology - Year 2017, Vol 4, Issue 3
Abstract
Burkitt’s lymphoma is rare B cell monoclonal malignant lymphoma with short doubling time (less than 3 days) occurring due to deregulation of c-myc oncogene. Most Burkitt’s lymphomas (80% to 90%) carry a translocation of the proto-oncogene c-myc from chromosome 8 to the immunoglobulin heavy chain region on chromosome 14 [t(8;14)]. In 10% to 20% of cases the c-myc gene is translocated to the kappa light chain loci on chromosome 2 [t(8;2)] or to the lambda light chain on chromosome 22 [t(8;22)]. Translocation leads to over-expression of the c-myc oncogene. Increased incidence is found in AIDS patients. In the sporadic form of the disease that occurs worldwide in non-endemic areas, mostly in developed countries, patients present with an abdominal mass that frequently involves the ileocecum in the bowel, whereas ocular or orbital involvement is rare.
Authors and Affiliations
Jayashri Thorat, Ranjana Bindu, Sujata Chahande, Smita Harne
Keywords
Related Articles
- EP ID EP259995
- DOI -
- Views 79
- Downloads 0
Ocular diseases other than refractive errors among school children of Aurangabad city of Maharashtra: A cross-sectional study
Background: Ocular diseases during childhood involve a wide variety of eye disorders that adversely affect all round development of the child. This cross-sectional study was done to assess the Ocular diseases other than...
A comparative assessment of voriconazole vs natamycin in treatment of mycotic corneal ulcer
Background: Mycotic corneal ulcer is endemic in tropical regions accounting for as many as half of corneal ulcers. Management of fungal keratitis requires timely diagnosis of the infection and administration of appropria...
Study of association of hyperthyroidism with intraocular pressure, dry eye and central corneal thickness
Purpose: To study the association of Hyperthyroidism on intra ocular pressure, dry eye and central corneal thickness.Materials and method: Study design: Case-control study. In our study we have included 100 hyperthyroid...
Study of indication of destructive ocular surgeries at Sagarmatha Choudhary eye hospital, Lahan
Background: To determine the indications for destructive ocular surgery in our hospital so that it would be useful in planning strategies and to reduce avoidable eye loses and associated challenges after destructive ocul...
A study of risk factors of age related macular degeneration in elderly patients attending OPD of ophthalmology in tertiary care hospital
Background: Age-related macular degeneration (AMD) is an important cause of visual impairment and blindness worldwide. The number of people affected by the disease is expected to rise due to increasing longevity. Develop...