Alcohol dehydrogenase – physiological and diagnostic Importance
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Alcohol dehydrogenase (ADH) is a polymorphic enzyme, existing in multiple isoenzymes divided into several classes and localized in different organs. ADH plays a significant role in the metabolism of many biologically important substances, catalyzing the oxidation or reduction of a wide spectrum of specific substrates. The best characterized function of ADH is protection against excess of ethanol and some other exogenous xenobiotics and products of lipid peroxidation. The isoenzymes of alcohol dehydrogenase also participate in the metabolism of retinol and serotonin. The total alcohol dehydrogenase activity is significantly higher in cancer tissues than in healthy organs (e.g. liver, stomach, colorectum). The changes in activity of particular ADH isoenzymes in the sera of patients with different cancers (especially of the digestive system) seem to be caused by release of these isoenzymes from cancer cells, and may play a potential role as markers of this cancer. The particular isoenzymes of ADH present in the serum may indicate the cancer localization. Alcohol dehydrogenase may also be useful for diagnostics of non-cancerous liver diseases (e.g. viral hepatitis, non-alcoholic cirrhosis).
Authors and Affiliations
Magdalena Łaniewska-Dunaj, Wojciech Jelski, Maciej Szmitkowski
Keywords
Related Articles
- EP ID EP67031
- DOI -
- Views 111
- Downloads 0
CXCL8 (interleukin 8) – the key inflammatory mediator in chronic obstructive pulmonary disease?
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic disease of the upper airways and it is the fourth cause of death in the Polish population. COPD is characterized by not fully reversible constriction of...
Interdisciplinary therapeutic application of potassium citrate in internal diseases
Citrates share both metabolic and excretory role. Through Krebs-cycle conversion they stimulate blood alkalization with biochemical-hormonal effects depending from the accompanying cation. The excretory function covers i...
Aktywność przeciwbakteryjna/przeciwbiofilmowa „przeterminowanych” płytek krwi i produktów ich degranulacji
Stres oksydacyjny w procesach przerostu i kancerogenezy gruczołu sterczowego
Procesy starzenia się organizmu w połączeniu z upośledzeniem równowagi oksydacyjno-redukcyjnej oraz infekcjami i stanem zapalnym stanowią uznane czynniki ryzyka procesów przerostowych i raka gruczołu sterczowego. Przewle...
The role of docosahexaenoic acid in neuronal function
Docosahexaenoic acid (DHA, C22: 6n-3) is the most abundant polyunsaturated fatty acid in neuronal phospholipids, particularly in the cortex. The main source of DHA for neural cells is food, and hepatic and astroglia DH...