Allogeneic hematopoietic cell transplantation: current state and future perspectives
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 6
Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) constitutes a standard treatment of hematological malignant and nonmalignant disorders. The possibilities of finding a donor has been increased by use of unrelated donors, with similar results to sibling donor transplants. The use of peripheral blood stem cells, instead of bone marrow, results in faster engraftment but also in increased risk of chronic graft-versus-host disease. Reduced-intensity conditioning is used instead of high-dose myeloablative conditioning for older patients and those with comorbidities. Disease relapse is a major problem which should be detected early as minimal residual disease or recurrent recipient chimerism and managed by immunotherapy with donor lymphocyte infusions. Novel diagnostic tools and anti-microbial drugs have reduced morbidity and mortality from infections.
Authors and Affiliations
Mirosław Markiewicz, Sławomira Kyrcz-Krzemień
Keywords
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