Amaranthus spinosus leaf extracts and its anti-inflamatory effects on cancer
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 1
Abstract
The fruits and vegetables generate phytochemicals by its nature such as flavonoids and antioxidants which can reduce the oxidative stress and lower risk of chronic sustainment like cancer. The present study was to investigate and evaluate the antitumor capacity and chemoprotective effects of Amaranthus Spinosus leaves. The methanol extracts of Amaranthus Spinosus leaves tested with different doses for different cell lines such as breast, colorectal, liver and normal cell lines. This was observed that the methanol leaf extract at different doses causes a decrease significant level of tumor development and viable cell count. Percentage of leaf Methanol extracts HEP G2, MCF-7 and HT-29 cells shows IC 50 values of less than 30ug/ml. Amaranthus Spinousus leaf extracts shown significant membrane stability property which shows better anti-inflammatory responses. FACS used to analysis the inhibition of cell cycle progressionsby using PI Staining for HEp G2 Cells. The results suggest that the methanol extracts of Amaranthus spinosus leaves reveals significant antitumor effects in cancers of breast, colorectal, liver and normal cell lines. Further studies are required to elucidate the precise molecular mechanisms and targets for cell growth inhibition.
Authors and Affiliations
S. Rajasekaran, M. G. Dinesh, Chandarasekharam Kansrajh, Fida Hussain Ahmed Baig
Keywords
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