Amelioration of Non-steroidal Anti-inflammatory Drug Induced Gastropathy by Nigella sativa Oil- An Experimental Study
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 10, Issue 2
Abstract
Aims: To evaluate the protective effect of Nigella sativa oil against Non-steroidal anti-inflammatory drug induced gastropathy. Methodology: Thirty wistar albino rats (15-200 gm) of either sex were divided into five groups each containing six animals. Group I & II were administered distilled water 0.5 ml daily p.o for 5 days, Group III was administered distilled water 0.5 ml daily p.o for 5 days and ranitidine 30 mg/kg p.o on 5th day and group IV & V were test groups, administered with Nigella sativa oil (NSO) at a dose of 1 & 2 ml/kg/day p.o respectively for 5 days. Except group I all groups were fasted for 36 hrs and on 5th day 1 hour after the last dose of ranitidine or test drug administration, aspirin 400 mg/kg p.o was administered in fasted rats. 5 hrs after aspirin administration the rats were sacrificed and gastric contents were analysed for pH and acid output while the stomach was taken out for ulcer index calculation and histological examination. Results: Aspirin caused marked gastric damage evidenced in group II which was prevented by ranitidine as well as Nigella sativa oil (NSO). Among the test groups the protection was in a dose dependent manner. Conclusion: Nigella sativa oil (NSO) showed a dose dependent protective effect against aspirin induced gastropathy.
Authors and Affiliations
Mohammed Nazer Hasan, Rahat Ali Khan, Mohammed Nasiruddin, Aijaz Ahmed Khan
Keywords
Related Articles
- EP ID EP350082
- DOI 10.9734/EJMP/2015/19932
- Views 96
- Downloads 0
Evaluation of Antibacterial Effects and Phytochemical Analysis of Lantana camara linn Leaf and Berry Extracts
In order to assess the antibacterial activities of methanolic and aqueous leaf extracts (MLE and ALE) as well as that of methanolic berry extract (MBE) of Lantana camara Linn, we screened each for antibacterial effects a...
Screening for Biological Activities of Medicinal Plants Used in Traditional Arabic Palestinian Herbal Medicine
Aims: To evaluate eleven medicinal plants as natural sources that possess strong antidermatophytic, antibacterial, anticandidal and antioxidant substances with potential applications in therapeutics and food industry. Pl...
Antibacterial and Antifungal Activity of Litsea monopetala Leaves on Selected Pathogenic Strains
Aims: To evaluate the antibacterial and antifungal activity of some solvent extracts of Litsea monopetala (LM) leaves. Study Design: Examination of antibacterial and antifungal activity of petroleum ether fraction (PEF),...
In vitro Antimicrobial and Antioxidant Analysis of Gallic Acid from the Leaves of Ludwigia abyssinica A. Rich
Aims: To evaluate the antimicrobial and antioxidant potentials of a biologically active compound isolated from the leaves of Ludwigia abyssinica A. Rich. Study Design: Antimicrobial and antioxidant analysis of compound f...
Characteristics of Ethanol Extract of Detam 1 Indonesian Soybean and Jati Belanda Leaves and the Effects of their Combinations on Weight Gain and Jejunum Histopathological Changes in Male Wistar Rats
Background: Anti-Nutritional-Factors (ANF) are natural or synthetic compounds that interfere with the absorption of nutrients. ANF may cause changes in the histopathology of the small intestinal mucosa, and may affect th...