Amelioration of Non-steroidal Anti-inflammatory Drug Induced Gastropathy by Nigella sativa Oil- An Experimental Study
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 10, Issue 2
Abstract
Aims: To evaluate the protective effect of Nigella sativa oil against Non-steroidal anti-inflammatory drug induced gastropathy. Methodology: Thirty wistar albino rats (15-200 gm) of either sex were divided into five groups each containing six animals. Group I & II were administered distilled water 0.5 ml daily p.o for 5 days, Group III was administered distilled water 0.5 ml daily p.o for 5 days and ranitidine 30 mg/kg p.o on 5th day and group IV & V were test groups, administered with Nigella sativa oil (NSO) at a dose of 1 & 2 ml/kg/day p.o respectively for 5 days. Except group I all groups were fasted for 36 hrs and on 5th day 1 hour after the last dose of ranitidine or test drug administration, aspirin 400 mg/kg p.o was administered in fasted rats. 5 hrs after aspirin administration the rats were sacrificed and gastric contents were analysed for pH and acid output while the stomach was taken out for ulcer index calculation and histological examination. Results: Aspirin caused marked gastric damage evidenced in group II which was prevented by ranitidine as well as Nigella sativa oil (NSO). Among the test groups the protection was in a dose dependent manner. Conclusion: Nigella sativa oil (NSO) showed a dose dependent protective effect against aspirin induced gastropathy.
Authors and Affiliations
Mohammed Nazer Hasan, Rahat Ali Khan, Mohammed Nasiruddin, Aijaz Ahmed Khan
Ameliorative Potentials of Methanol Extract and Chloroform Fraction of Drymaria cordata on MSG-induced Uterine Hyperplasia in Female Wistar Rats
Aim: Uterine fibromyomas are non-cancerous or benign growth of the uterus. They are sensitive to changes in levels of oestrogen and progesterone which affect the size of the fibroid. It has been well established that glu...
Antibiotic Potential of Moringa Leaf (Moringa oleifera Lam.) Crude Extract in Bull Semen Extender
Aim: The effect of Moringa oleifera crude extract (MOCE) was carried out on Friesian bull semen for its antibiotic potential. Design of the Experiment: The design of the experiment was completely randomized design. Place...
Evaluation of Haemolytic Activity of Leaves from Acacia podalyriifolia
Acacia podalyriifolia A. Cunn ex G. Don (Fabaceae) is a plant used in south Brazil for ornamental purposes. The leaves are used in folk medicine for the treatment of bacterial infection, diabetes, gastrointestinal distur...
Protective Properties of Citrullus lanatus on Carbon Tetrachloride Induced Liver Damage in Rats
Aim: This study was conducted to investigate the effects of the leaf extract of Citrullus lanatus on carbon tetrachloride (CCl4) induced liver damage in rats. Methodology: Hepatoprotective study was conducted using five...
Fibroblast Growth Stimulation, DPPH Antioxidant Assay and Antimicrobial Activities of Funtumia elastica (Preuss) Stapf (Apocynaceae) Leaf Extracts
Aims: To investigate the scientific basis for the wound-healing properties of Funtumia elastica (Apocynaceae) leaf extracts using relevant in vitro fibroblast growth stimulation, antimicrobial and DPPH-antioxidant assays...