Ameliorative effect of Alpinia galanga rhizomes on Freund's complete adjuvant induced arthritis in mice
Journal Title: Asian Journal of Pharmacy and Pharmacology - Year 2015, Vol 1, Issue 2
Abstract
Arthritis is a inflammatory autoimmune disorder resulting in joint that is marked by swelling, pain, functional destruction and muscle wasting. The objective of present study was to evaluate rhizomes of Alpinia galanga for Freund’s complete adjuvant induced arthritis in mice model. Materials and methods: Ethanolic extract with the dose of 100 and 200mg/kg was tested for antiarthritic activity using Freund’s complete adjuvant model in mice. Activity was measured by paw edema measurement and observation of haematological parameters i.e. Leukocyte Count, Packed Cell Volume (PCV), and Rheumatoid Factor (RF), in the serum 28th days after CFA administration. Results: Antiarthritic potential of ethanolic extract found on dose dependent manner and 200mg/kg dose of extract was significantly observed. Results also supported by improved various inflammatory markers in plasma. Conclusion: Study can be concluded that the effect of ethanolic extract may be due to presence of flavonoids in the extract.
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