Ameliorative Effect of Aqueous Leaf Extract of Tectona Gondis on Egg Yolk Induced Heart and Blood Vessels Damage in Adult Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
The aim of this study was to determine the effect of aqueous extract of Tectona gondis leaf on egg yolk induced heart and blood vessel toxicity in adult wistar rats. A total of 35 (thirty five) adult wistar rats weighing between 200 g to 270 g were divided into 5 groups of seven rats per group. Group A rats were placed on normal diet only while Group B rats received 300 mg/ kg body weight / day (BWT/D) of egg yolk. Group C rats received 300mg / kg BWT/D of Tectona gondis leaf. Group D rats received 300 mg/ kg BWT/D of egg yolk and 300mg / kg BWT/D of T. gondis leaf Group E rats received 300 mg/ kg BWT/D of egg yolk and 500mg / kg BWT/D of T. gondis leaf and all the dosage were given for 30 days via orogastric administration. The biochemical result revealed that group B showed marked increase in the level of the serum SOD, CAT, cholesterol when compared with the other groups. Histologically, group B showed asevere vascular obstruction and mild perivascular infiltrates of chronic inflammatory cells, while group A,C,D and E revealed normal bundles of myocardial fibers and coronary artery. It can then be concluded that theaqueous leaf extract of T. gondis was able to reverse the vascular obstruction of the coronary artery caused by the egg yolk.
Authors and Affiliations
EHIMIGBAI, Agbonluai Richard . O1, MIEHWEE, Goodluck . O. , EHI-OMOSUN, Mabel1
Keywords
Related Articles
- EP ID EP386763
- DOI 10.9790/3008-110602889
- Views 73
- Downloads 0
Moringa Oleifera, A Potential Miracle Tree; A Review
Moringa oleifera Lam. Tree grows in many tropical and subtropical countries. It is grown for commercial purposes in places like South and Central America, Africa, India, Hawaii, Mexico and Asia. The seed, leaves, root an...
Identification of lead compounds against human hepatitis B viral capsid protein in three medicinal plants through in silico method
Hepatitis B viral infection is a serious health problem in all over the world and its treatment is expensive with limited success (30-40%. The current treatment system may induce serious side effects. It is well acknowle...
Ethnobotanical Importance Of Zingiber In The Imphal Valley District, Manipur With Zingiber Chrysanthum Roscoe as A New Record For Manipur.
The Zingiberaceae is rich in species used as traditional medicines or spices, but extensive information about their chemistry and pharmacology is available for ginger ( Zingiber officinale). Throughout the history of for...
Synthesis, Identification and Evaluation the Biological Activity for Some New Heterocyclic Compounds Derived from Schiff Bases
This research involves synthesis some of new tetrazole, imidazolinone, thiazolidinone, and oxazepine derivatives. The first step includes formation Schiff bases (1-5) from condensation N-[(4-aminophenyl) carbamothioyl] b...
Pharmacognostic Studies on the Stem bark of Albizia chevalieri (Fabaceae).
Studies on the macro-morphological, microscopic, chemo microscopic were made on the stems of Albizia chevalieri. Morphologically the stems are of variable in size and ,somewhat cylindrical in shape, light grey in colour...