Ameliorative Effect of Aqueous Leaf Extract of Tectona Gondis on Egg Yolk Induced Heart and Blood Vessels Damage in Adult Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
The aim of this study was to determine the effect of aqueous extract of Tectona gondis leaf on egg yolk induced heart and blood vessel toxicity in adult wistar rats. A total of 35 (thirty five) adult wistar rats weighing between 200 g to 270 g were divided into 5 groups of seven rats per group. Group A rats were placed on normal diet only while Group B rats received 300 mg/ kg body weight / day (BWT/D) of egg yolk. Group C rats received 300mg / kg BWT/D of Tectona gondis leaf. Group D rats received 300 mg/ kg BWT/D of egg yolk and 300mg / kg BWT/D of T. gondis leaf Group E rats received 300 mg/ kg BWT/D of egg yolk and 500mg / kg BWT/D of T. gondis leaf and all the dosage were given for 30 days via orogastric administration. The biochemical result revealed that group B showed marked increase in the level of the serum SOD, CAT, cholesterol when compared with the other groups. Histologically, group B showed asevere vascular obstruction and mild perivascular infiltrates of chronic inflammatory cells, while group A,C,D and E revealed normal bundles of myocardial fibers and coronary artery. It can then be concluded that theaqueous leaf extract of T. gondis was able to reverse the vascular obstruction of the coronary artery caused by the egg yolk.
Authors and Affiliations
EHIMIGBAI, Agbonluai Richard . O1, MIEHWEE, Goodluck . O. , EHI-OMOSUN, Mabel1
Keywords
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- EP ID EP386763
- DOI 10.9790/3008-110602889
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