Identification of lead compounds against human hepatitis B viral capsid protein in three medicinal plants through in silico method
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Hepatitis B viral infection is a serious health problem in all over the world and its treatment is expensive with limited success (30-40%. The current treatment system may induce serious side effects. It is well acknowledged that plant-derived drug molecules are safe and cost effective. In traditional medicine several plants have been used as hepatoprotective but its efficacy and mode of molecular mechanism of drug action are seldom investigated. In the present investigation, 92 phytochemicals from three plant species viz., Allamanda cathartica L., Solanum indicum L. and Vigna mungo L., which have been used as hepatoprotective plants in Indian traditional systems of treatment, were docked with the HBc protein. The structures of phytochemicals were procured from open access databases or drawn using MarvinSketch and 3D structure of the target protein, HBc was downloaded from protein data bank (PDB ID: 1QGT). Docking was carried out in AutoDock 4.2 and the results indicated that all the three plants have anti-hepatitis B activity and among the three plants the most potential lead molecule; carpesterol was identified from Solanum indicum.
Authors and Affiliations
Subin Mathew M S1, Sreekumar S2, Biju C K3
Keywords
Related Articles
- EP ID EP384450
- DOI 10.9790/3008-1103010106
- Views 79
- Downloads 0
Efficacy of the bioactive compounds of medicinal importance in the leaves of Lantana camara L. and Andrographis paniculata (Burm. f.) Wall. ex Nees
The present study includes the phytochemical detection and antimicrobial activity of the leaves of Lantana camara L. and Andrographis paniculata (Burm. f.) Wall. ex Nees. Phytochemical screening of the leaf extract of le...
Comparison of major peanut allergens Ara h 1, Ara h 2 and Ara h 3 between peanut cultivars from Côte d’Ivoire and the USA using SDS PAGE and Western Blots
Peanut is commonly consumed in many forms. The ubiquitous presence of peanut in processed food is responsible for an increasing number of allergic reactions due to accidental ingestion. The prevalence of peanut allergy s...
Are The Fruiting And Non-Fruiting Acrocarpous Moss Barbula indica (Hooker) Sprengel in Nigeria Distinct Species?
Barbula indica (Pottiaceae), a dioecious acrocarpous moss had never been found with sporophytes in Nigeria. The occurrence of fruiting B. indica from two populations in the Nigerian forest and derived savanna is reported...
Congenital Chloride Diarrhoea
Congenital chloride losing diarrhea (CLD) is a medical emergency case in pediatrics. It is a rare genetic disorder caused due to mutation of chromosome 7.It is commonly seen in Saudi Arabic countries ,It is seen in early...
Levels of Heavy Metals in Some Soup Thickeners Used In Abomege in Ebonyi State, Nigeria
Samples of Afzelia Africana, Brachystogia Nigerica and Macuna-sloanei, were collected from Abaomege in Onicha L.G.A of Ebonyi State and were analyzed for heavy metals using Atomic Absorption Spectrophotometer (Bulk scien...