Ameliorative Effect of Nigella sativa Oil against Paracetamol Induced Hepatic and Renal Damages in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 13, Issue 3
Abstract
Aims: To evaluate the protective effect of Nigella sativa oil against Non-steroidal anti-inflammatory drug induced hepatic and renal damages in rats. Methodology: Study was conducted on 24 Wistar albino rats (150-200 g) of either sex. They were divided into four groups each containing six rats. Group I was treated with distilled water only, Group II treated with Paracetamol (750 mg/kg) only and Group III to IV were test groups treated with Paracetamol (750 mg/kg) and Nigella sativa oil (1 & 2 ml/kg respectively) for 7 days. On 8th day all rats were sacrificed and blood were collected for liver and renal function tests and tissue samples for histo-pathological examination. Results: Paracetamol caused marked hepatic and renal damages which were prevented by Nigella sativa oil in dose dependent manner. Conclusion: Nigella sativa oil showed significant hepato- and reno-protection against Paracetamol induced damages.
Authors and Affiliations
Mohammed Nazer Hasan, Rahat Ali Khan, Mohammed Nasiruddin, Aijaz Ahmed Khan
Keywords
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- EP ID EP342217
- DOI 10.9734/BJPR/2016/27597
- Views 86
- Downloads 0
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