Amoxicillin clavulanic acid resistance in pus samples sent for culture sensitivity - The scenario in a tertiary care hospital, Ballari
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: Amoxicillin Clavulanic Acid (AMC) is a broad-spectrum antibacterial being used over 20 years. Emergence of resistant bacteria has complicated the empirical therapy of infections. Resistance to Amoxicillin is a matter of concern. Clavulanic acid, a β-lactamase inhibitor, is used to overcome resistance. But appearance of resistance to even this combination is a matter of even more concern. Hence an attempt is made to find out the proportion of resistance to AMC in a tertiary care setup. Aim: To evaluate the pattern of resistance to Amoxicillin Clavulanic acid (AMC) among organisms isolated from pus samples sent for culture sensitivity. Material and Methods: This record based descriptive study, taken up to evaluate the resistance pattern of culture isolates of pus samples from various departments. Pus culture and sensitivity reports obtained by Kirby Bauer Disc diffusion method of pus samples during a period of 6 months was collected from Microbiology Department. Data obtained were tabulated and analysed using descriptive statistical methods. Results: A total of 245 reports were analysed. Most common organism isolated (I) and its resistance (R) was Staphylococcus (I:46.53%; R:61.4%), followed by E.coli (I:19.59%; R:87.5%), Pseudomonas (I:14.29%; R:62.85%), Klebsiella (I:11.43%; R:85.71%), Citrobacter (I:3.27%; R:100%), Streptococci (I:2.04%; R:0%), Proteus (I:1.63%; R:75%), Enterobacter (I:0.82%; R:50%) and Acetobacter (I:0.4%; R:0%). 69.4% of sample culture isolates were found to be resistant to AMC. Conclusion: This study reports the most commonly encountered organism in pus samples to be Staphylococcus, followed by E.coli, Pseudomonas and Klebsiella. Nearly 70% of organisms causing purulent infections were resistant to AMC. Of the isolates, statistically significant resistance was shown by E.coli followed by Klebsiella and Staphylococcus.
Authors and Affiliations
Murgesh J V, Vishwanath M, Prashanth S P
Keywords
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