Amoxicillin clavulanic acid resistance in pus samples sent for culture sensitivity - The scenario in a tertiary care hospital, Ballari
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: Amoxicillin Clavulanic Acid (AMC) is a broad-spectrum antibacterial being used over 20 years. Emergence of resistant bacteria has complicated the empirical therapy of infections. Resistance to Amoxicillin is a matter of concern. Clavulanic acid, a β-lactamase inhibitor, is used to overcome resistance. But appearance of resistance to even this combination is a matter of even more concern. Hence an attempt is made to find out the proportion of resistance to AMC in a tertiary care setup. Aim: To evaluate the pattern of resistance to Amoxicillin Clavulanic acid (AMC) among organisms isolated from pus samples sent for culture sensitivity. Material and Methods: This record based descriptive study, taken up to evaluate the resistance pattern of culture isolates of pus samples from various departments. Pus culture and sensitivity reports obtained by Kirby Bauer Disc diffusion method of pus samples during a period of 6 months was collected from Microbiology Department. Data obtained were tabulated and analysed using descriptive statistical methods. Results: A total of 245 reports were analysed. Most common organism isolated (I) and its resistance (R) was Staphylococcus (I:46.53%; R:61.4%), followed by E.coli (I:19.59%; R:87.5%), Pseudomonas (I:14.29%; R:62.85%), Klebsiella (I:11.43%; R:85.71%), Citrobacter (I:3.27%; R:100%), Streptococci (I:2.04%; R:0%), Proteus (I:1.63%; R:75%), Enterobacter (I:0.82%; R:50%) and Acetobacter (I:0.4%; R:0%). 69.4% of sample culture isolates were found to be resistant to AMC. Conclusion: This study reports the most commonly encountered organism in pus samples to be Staphylococcus, followed by E.coli, Pseudomonas and Klebsiella. Nearly 70% of organisms causing purulent infections were resistant to AMC. Of the isolates, statistically significant resistance was shown by E.coli followed by Klebsiella and Staphylococcus.
Authors and Affiliations
Murgesh J V, Vishwanath M, Prashanth S P
Keywords
Related Articles
- EP ID EP471395
- DOI 10.26611/1010821
- Views 105
- Downloads 0
Safety profile of atorvastatin in post myocardial infarction and post stroke patients
Background: The side effects of high dose atorvastatin treatment in post myocardial infarction and post stroke patients have not been studied in detail. The present work aim to study whether the toxicity profile of atorv...
Effect ofaddition of trimetazidine on LV function in patients with LV systolic dysfunction receiving optimal medical therapy in comparison with patients receiving only optimal medical therapy in a tertiary care centre
Background: Left ventricular dysfunction (LVD) can lead to congestive cardiac failure.LVD was traditionally managed by antiplatelets, diuretics, antihypertensives and statins. However studies have shown that addition of...
A study of drug utilization pattern of analgesics in postoperative patients of tertiary care hospital
Background and Objectives: Postoperative pain is the pain developed after surgical trauma and due to inflammatory reaction. Analgesic prescribed to postoperative patients differ with different patients, as pain is subjec...
Comparison of effects of metformin with combination of glimepride and metformin in type 2 diabetes patients
Background: The use of a fixed-dose combination pill of sulfonylurea and metformin has recently increased. Using a fixed-dose combination pill can improve patient compliance. Aim: To compare the effects of tformin with c...
Effect of ciprofloxacin: A fluoroquinolone drug on psychomotor performance tests and blood sugar level in healthy humans
Background: Fluoroquinolones are widely used for infections butcan affect psychomotor function. Ciprofloxacin is known to cause anxiety, impairment of concentration, abnormal vision. Previous studies indicated a relation...