Safety profile of atorvastatin in post myocardial infarction and post stroke patients
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 9, Issue 1
Abstract
Background: The side effects of high dose atorvastatin treatment in post myocardial infarction and post stroke patients have not been studied in detail. The present work aim to study whether the toxicity profile of atorvastatin in Indian population is same as that of western countries. There are reports that atorvastatin decreases C-reactive protein levels in blood. This study further target to find whether the reduction in C-protein levels are dose dependent about which no conclusive data is available. Methodology: This observational prospective study was conducted in the subjects admitted with acute myocardial infarction or cerebrovascular accident in the form of infarct and started on atorvastatin as a part of treatment. 100 subjects in the age group 35-75 years were chosen and they were categorized into two different groups. The 1st group had subjects who were taking 10 mg and the 2nd, 40 mg of atorvastatin. The comparison of serum creatinine, serum uric acid, serum glutamate pyruvate transaminase (SGPT) and creatinine phosphokinase (CPK) were measured. They were followed up twice (at 6 weeks and 12 weeks) during the study period of 3 months and adverse effects were carefully monitored by clinical parameters and laboratory investigations. Results: After the 12 weeks study period, it was found that atorvastatin is well tolerated in low and high doses with minimal side effects and no dose response relationship was found in overall incidence of adverse effects. Besides, the reduction in C-reactive protein values with atorvastatin therapy following coronary and cerebrovascular events was not dose dependent. Conclusion: There is no significant difference in adverse outcome as far as low dose or high dose of atorvastatin usage is concerned in post coronary or cerebrovascular event therapy. And in addition the drug appeared to be safe and did not produce any major side effects in the study population during this trial.
Authors and Affiliations
Mohamed Salim Valiyakathody, Soopy Kayanaduth, Roopashree Gopinath, R E Muneer
Keywords
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- EP ID EP471386
- DOI 10.26611/1010911
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