Preclinical evaluation of hypolipidemic effect of hesperidin in high cholesterol diet model in wistar albino rats
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 10, Issue 1
Abstract
Background:Hyperlipidemia is a major cause of various coronary heart diseases. Early diagnosis and initiation treatment can reduce the mortality. The present study aimed to evaluate the hypolipidemic effect of hesperidin in high cholesterol rats. Materials and Methods: Wister Albino rats weighing 200-250gm were used in this study. 24 rats were divided into four groups each of 6 rats. G-I (Normal diet), G-II (High cholesterol diet), G-III (High cholesterol diet + Hesperidin 100 mg/kg) and G-IV (High cholesterol diet + Hesperidin 200 mg/kg). Four groups tetrad with respective drugs for 90 days. At the end of experiment blood and hepatic samples were collected and used for estimation of total cholesterol, triglycerides, HDL, LDL and VLDL. SPSS software used for statistical analysis. Data was expressed in mean and standard deviation. Results: Group-I showed significant effect in lipid profile compared to group-II. Group-III and IV showed significant results in lipid profile compared to Group-I and II. Group-IV showed better effect than group-III. Similar effects were observed in hepatic lipid profile. Conclusion: Animals treated with hesperidin showed significant effect on blood and hepatic lipid profile. From the study results it can be concluded that hesperidin can be used in the prevention and treatment of hyperlipidemia.
Authors and Affiliations
Pradeep Kumar V, Vijai Sundar E
Keywords
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