“An estimation of Serum Prednisolone in Children with Nephrotic Syndrome: A study in a tertiary care hospital, Dhaka, Bangladesh”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Poor absorption of prednisolone is very uncommon, but an absorption study may be useful confirmatory evidence of poor concordance in a patient who denies not taking Prednisolone. Nephrotic syndrome, or nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. While nephrotic-range proteinuria in adults is characterized by protein excretion of 3.5 g or more per day but in children it is defined as protein excretion of more than 40 mg/m2/h or a first-morning urine protein/ creatinine of 2-3 mg/mg creatinine or greater. Prednisolone is a steroid medication used to treat children with nephrotic syndrome which is frequently used. The aim of this study was to estimate serum Prednisolone in children with nephrotic syndrome in active phase and in remission. This was an prospective observational study done in the department of Paediatric Nephrology & Kidney diseases, Dhaka Shishu (Children) Hospital, Sher - E - Bangla Nagar, Dhaka and Clinical Pharmacy & Pharmacology Dept. University of Dhaka from January 2014 to December 2014. Serum Prednisolone was measured by enzymatic colorimetric method. The serum Prednisolone was measured in nephrotic syndrome during active phase & in remission and the average values were 2.088795 mic. mol/ml & 2.175277 mic.mol/ml respectively which was significantly high in remission of NS.
Authors and Affiliations
Dr. Abu Bakkir Siddique, Dr. Mahmudul Hoque Chowdhury, Dr. Md. Kamruzzaman, Dr. Md. Mosharaf Hossain
Keywords
Related Articles
- EP ID EP406716
- DOI 10.9790/0853-1710116064.
- Views 78
- Downloads 0
Hypereosinophilic Syndrome with Loeffler Endocarditis, A Rare Case of Heart Failure in A Child
Abstract: An eight-yr-old girl presented with history of progressive dyspnoea and cough for 12 days with fatigue and rapid worsening of symptoms. There was features of cardiogenic shock ,congestive cardiac failure and mi...
Retrospective Observational Study Of Platlet Count In Dengue Fever With IGM Positive Casesinteritiary Care Hospital.
Background: Arthropod borne viral diseasecaused by flvivirus transmitted by aedesaegypti mosquito. Objectives: To study the platlet count in IgM positive cases of dengue fever in tertiary care hospital, anantapuramu.Andh...
Venous Leg Ulcer - Management Experience In A Tertiary Healthcare Center In Eastern India
Introduction: venous ulcer is most common type of chronic leg ulcer. In this study we have tried to summarize the experience of venous ulcer treatment in RIMS,Ranchi; a tertiary healthcare center in eastern India. Materi...
“A Reviewof Role of Nasya Karma in Gynaecological Disorders”
Nasya Karma is the specific treatment methodology in Ayurveda in which drug is administered through Nasal route. This particular type of treatment is mainly indicated for the disorders in the head and neck region. In pre...
Prevalence of Vitamin-D deficiency in Ulcerative Colitis
INTRODUCTION: Ulcerative colitis is a chronic inflammatory disease of the colon of unclear etiology with an increasing incidence in India. Immunomodulatory effects of vitamin-D has been linked to autoimmune disease such...