“An estimation of Serum Prednisolone in Children with Nephrotic Syndrome: A study in a tertiary care hospital, Dhaka, Bangladesh”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Poor absorption of prednisolone is very uncommon, but an absorption study may be useful confirmatory evidence of poor concordance in a patient who denies not taking Prednisolone. Nephrotic syndrome, or nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. While nephrotic-range proteinuria in adults is characterized by protein excretion of 3.5 g or more per day but in children it is defined as protein excretion of more than 40 mg/m2/h or a first-morning urine protein/ creatinine of 2-3 mg/mg creatinine or greater. Prednisolone is a steroid medication used to treat children with nephrotic syndrome which is frequently used. The aim of this study was to estimate serum Prednisolone in children with nephrotic syndrome in active phase and in remission. This was an prospective observational study done in the department of Paediatric Nephrology & Kidney diseases, Dhaka Shishu (Children) Hospital, Sher - E - Bangla Nagar, Dhaka and Clinical Pharmacy & Pharmacology Dept. University of Dhaka from January 2014 to December 2014. Serum Prednisolone was measured by enzymatic colorimetric method. The serum Prednisolone was measured in nephrotic syndrome during active phase & in remission and the average values were 2.088795 mic. mol/ml & 2.175277 mic.mol/ml respectively which was significantly high in remission of NS.
Authors and Affiliations
Dr. Abu Bakkir Siddique, Dr. Mahmudul Hoque Chowdhury, Dr. Md. Kamruzzaman, Dr. Md. Mosharaf Hossain
Keywords
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- EP ID EP406716
- DOI 10.9790/0853-1710116064.
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