AN ION CHROMATOGRAPHIC METHOD FOR ESTIMATION OF METHANE SULPHONIC ACID IN GEMIFLOXACIN MESYLATE
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
The development and validation of an Ion chromatographic method for estimation of methane sulphonic acid in gemifloxacin mesylate drug substance was performed using acetone and buffer (1:9) as mobile phase and metrosep anion dual 2 as stationary phase at 0.5ml/min as flow rate. The analytes were monitored using suppressed conductivity detectors and linearity was obtained at the concentration range of 35.02 to 65.48 μg/ml and the correlation coefficient was found to be 0.9989. The recovery was found to be in the range of 103.53 to 116.30%w/w.
Authors and Affiliations
Kalpana Vasanthan
Keywords
Related Articles
- EP ID EP129343
- DOI -
- Views 135
- Downloads 0
TREATEMNET OF CANCER BY MEDICINAL MUSHROOMS
A term combining the words “nutrition” and “pharmaceutical,” is a food or food product that provides health and medical benefits, including the prevention and treatment of diseases. They have shown activities like antiox...
FORMULATION APPROACHES IN OCULAR DRUG DELIVERY SYSTEM
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex lachrymation and drainage which remove rapidly various foreign substances includin...
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL<br /> THIAZOLOQUINAZOLINE AS NEW CLASS OF H1-ANTIHISTAMINIC AGENT
A series of novel 6,7,8,9 tetra hydro-5H-5-(2'-hydroxy phenyl)-2-(4'-some substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline were synthesized the reaction with appropriate aromatic aldehydes and p –nit...
FORMULATION AND EVALUATION OF MUCOADHESIVE TABLETS OF BACLOFEN
The purpose of this research work was to establish mucoadhesive buccal tablets of Baclofen in the forms of monolayered tablets. The tablets were prepared using Sodium methyl cellulose (NaMC ), sodium alginate and Methoce...
DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND ATORVASTATIN CALCIUM IN BULK AND TABLET DOSAGE FORM
An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of Telmisartan and Atorvastatin calcium in a binary mixture. In the proposed method, the signals were measured...