AN ION CHROMATOGRAPHIC METHOD FOR ESTIMATION OF METHANE SULPHONIC ACID IN GEMIFLOXACIN MESYLATE
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
The development and validation of an Ion chromatographic method for estimation of methane sulphonic acid in gemifloxacin mesylate drug substance was performed using acetone and buffer (1:9) as mobile phase and metrosep anion dual 2 as stationary phase at 0.5ml/min as flow rate. The analytes were monitored using suppressed conductivity detectors and linearity was obtained at the concentration range of 35.02 to 65.48 μg/ml and the correlation coefficient was found to be 0.9989. The recovery was found to be in the range of 103.53 to 116.30%w/w.
Authors and Affiliations
Kalpana Vasanthan
Keywords
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