AN UPDATED REVIEW ON DESIGN OF EXPERIMENT (DOE) IN PHARMACEUTICALS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 3
Abstract
DoE is a structured, organized method for determining the relationships among factors affecting a process and its output.It has been suggested that DoE can offer returns that are four to eight times greater than the cost of running the experiments in a fraction of the time that it would take to run one-factor-at-a-time experiments.It is always important before beginning experimentation to determine the objective of an experiment, and this is no different with DoE. Identifying objectives helps focus a team on its specific aims (scientific understanding of the task/problem in hand) over a period of time. It also helps indicate what resources are and assists in managing expectations from a study’s outcome. DoE studies in support of QbD are often a delicate balance between delivering defined, high-quality products and meeting predetermined time, labor, and financial constraints. Keywords: Quality by design (QbD), Design of experiment (DoE), Process analytical technologies (PAT), One factor at a time (OFAT), Quality risk management (QRM), Critical process parameters (CPP), Analysis of variance (ANOVA)
COMPARATIVE IN VITRO EVALUATION OF DIFFERENT BRANDS OF NIFEDIPINE 20mg RETARD TABLET PRODUCTS MARKETED IN ADDIS ABABA, ETHIOPIA
Nifedipine has been formulated and marketed as extended-release-film coated tablet. A certain degree of success has been achieved in reducing the incidence of adverse effects by the use of slow-release formulations such...
COMPARATIVE STUDY OF CARICA PAPAYA WITH MARKETED PRODUCT FOR THE TREATMENT OF WOUNDS IN DIABETIC RODENTS
Diabetes is an unending situation associated with peculiarly elevated levels of sugar (glucose) in the blood. This chronic illness is also related with the degenerative extended pathological disorders like retinopathies,...
SCOPE OF PHARMACIST ON FUTURE ASPECT
Pharmacy is a profession started in India early in 20th Century. Since then, it has undergone many changes educationally and professionally. The Profession of Pharmacy is Associate in Nursing integral a part of the aid s...
A COMPARATIVE STUDY OF MORPHOLOGICAL AND ANATOMICAL STRUCTURES OF FOUR OCIMUM SPECIES IN UTTARAKHAND, INDIA
In traditional systems of medicine along with holistic approach, different parts of basil (Ocimum spp.) have been prescribed for the treatment of various ailments. Morphological and anatomical characters play a vital rol...
COMPARATIVE EVALUATION OF AMISULPRIDE AND ESCITALOPRAM ON SHEEHAN’S DISABILITY SCALE AMONG DEPRESSION PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL IN NEPAL
Introduction and Aim: Depression is an important global public health problem due to its relatively high lifetime prevalence and significant disability caused by it. The present study was conducted to compare improvement...