Analysis of anemia-related factors and transfusion status in premature infants
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 6
Abstract
Objective To analyze the risk factors of anemia in premature infants and the status of blood transfusion. Methods Clinical data of preterm infants with age ≤48 hours and hospitalization time ≥7 days, admitted to our hospital from August 2018 to July 2019, were collected. According to the Hb value, they were divided into the anemia group and the non-anemia group. The general information, disease occurrence, and treatment measures during hospitalization of the two groups were compared, and the risk factors affecting anemia were analyzed. Results A total of 169 cases were included in this study, including 88 cases in the anemia group and 81 cases in the non-anemia group. There were statistically significant differences between two groups in assisted reproduction 47(53.409) vs 33(40.741), basic Hb value 180.395(176.282, 184.508) vs 162.841(158.596, 167.085), maternal pregnancy anemia 27(30.682) vs 12(14.815), late-onset sepsis(LOS) 64(72.727) vs 31(38.272), mechanical ventilation 46(52.273) vs 10(12.346), neonatal respiratory distress syndrome(NRDS) 51(57.955) vs 26(32.099), coagulation dysfunction 27(30.682) vs 11(13.580) and average hospitalization days 31.276(26.885, 35.666) vs 15.798(14.251, 17.344), all P<0.05. Multivariate logistic results showed assisted reproduction, maternal pregnancy anemia, mechanical ventilation, coagulation dysfunction and average hospitalization days ≥20 were risk factors for preterm anemia. A total of 40 cases(23.669%) needed RBC transfusion to correct anemia during hospitalization, including 21 cases of very low birth weight infants(VLBWI). 8 patients(38.095%) received RBC transfusion ≥3 times during VLBWI hospitalization. The incidence of bronchopulmonary dysplasia(BPD) in the multiple transfusion group(≥3 times of RBC transfusion) was higher than in the non-multiple transfusion group. Conclusion Maternal anemia during pregnancy, assisted reproduction, mechanical ventilation, coagulation dysfunction and average hospitalization days are the related factors affecting the occurrence of anemia. The occurrence of BPD may be associated with multiple blood transfusions, but there is no clear evidence to prove that blood transfusion is an independent risk factor for the development of BPD, and a large sample, multi-center study is needed.
Authors and Affiliations
Qi LI, Yudan LI, Jing XU, Dong LI
Keywords
Related Articles
- EP ID EP738265
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.06.007
- Views 79
- Downloads 0
Analysis of risk factors for hemorrhage during CT-guided lung biopsy based on a random forest model
Objective To systematically analyze and identify key risk factors for postoperative pulmonary hemorrhage using a combination of the random forest (RF) model and traditional logistic regression analysis, so as to provide...
Retrospection and multivariate Logistic regression analysis of unqualified blood testing among voluntary blood donors in Guangzhou
Objective To retrospectively analyze the unqualified blood screening results of voluntary blood donors in Guangzhou area during 2016~2020, and analyze various factors that affect the blood screening results, for the purp...
Research progress of platelet lysates in the field of regenerative medicine and cell therapy
Human platelet lysates(HPL), as a new type of biomaterial, can promote tissue repair, cell proliferation and inflammation control. This paper introduced the development of HPL in the field of regenerative medicine and ce...
Effect of red blood cell preservation solution on serum agglutination reaction of specific patients
Objective To explore the precautions of pre-transfusion examination in patients with antibodies to erythrocyte protective solution, discrepant ABO blood typing results, and positive unexpected antibodies, so as to ensure...
Ambiguous blood matching caused by multiple blood transfusions resulting in anti-C, anti-JKb combined with Anti-Wra: a case report
Objective To study the reasons for ambiguous blood matching in a patient who received multiple blood transfusions, and explore how to reduce the risk of producing homologous antibodies in patients who received multiple b...